To compare the effect of prophylactic infusion of intravenous phenylephrine, nor epinephrine and mephentermine for maintenance of blood pressure in patients undergoing elective caesarean section under spinal anesthesia
Phase 2
- Conditions
- Health Condition 1: O00-O9A- Pregnancy, childbirth and the puerperium
- Registration Number
- CTRI/2020/12/030039
- Lead Sponsor
- kalinga institute of medical sciences
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Open to Recruitment
- Sex
- Not specified
- Target Recruitment
- 0
Inclusion Criteria
1.Age 21-40 years
2.ASA II
3.Singleton term pregnancy
4.Elective caesarean section
5.Parturient with no co-morbidity
Exclusion Criteria
1.Pre-existing pregnancy-induced
hypertension
2.Cardiovascular disease
3.Hepato-renal disease
4.Use of cardiac medication or medication
for blood pressure control
5.Gestational diabetes mellitus requiring
insulin
6.Suspicion of abnormal placentation
7.Allergy to study drugs
8.Intraoperative use of uterotonic other
than oxytocin
9.Known fetal abnormality
10.Contraindication to subarachnoid block
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method �To compare the effect of prophylactic infusion of intravenous phenylephrine, nor epinephrine and mephentermine for maintenance of blood pressure in patients undergoing elective caesarean section under spinal anesthesia .Timepoint: Blood pressure and heart rate recorded every 2 minutes until delivery.
- Secondary Outcome Measures
Name Time Method Incidence of bradycardia,hypertension,hypotension. <br/ ><br>-Total doses of rescue drug required. <br/ ><br>-Neonatal APGAR scores at 1 and 5 minutes. <br/ ><br>-To find the incidence of post operative nausea and vomiting. <br/ ><br> <br/ ><br>Timepoint: Blood pressure and heart rate recorded every 2 minutes until delivery.