A Randomised Comparative Study To Compare Efficacy Of Intravenous Lignocaine Versus Labetalol Versus Esmolol For Attenuating The Haemodynamic Response To Laryngoscopy And Endotracheal Intubation At S.M.S Medical College Jaipur.
试验速览
- 阶段
- 4 期
- 状态
- 尚未招募
- 发起方
- 入组人数
- 153
- 试验地点
- 1
- 主要终点
- To assess and compare the effect of intravenous lignocaine verus labetalol versus esmolol on haemodynamic parameters (HR,SBP,DBP,MAP) to laryngoscopy and endotracheal intubation.
研究概览
简要总结
This randomized controlled study is aimed to study the effects of intravenous lignocaine (1mg per kg) versus intravenous labetalol (0.25mg per kg) versus intravenous esmolol (0.5mg per kg) for attenuating the haemodynamic response to laryngoscopy and endotracheal intubation in patients undergoing elective surgeries under general anaesthesia. Patients are randomly assigned to receive either iv lignocaine ,iv labetalol or iv esmolol during the perioperative period. Haemodynamic parameters and side effects assesed at different intervals post intubation .
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 盲法
- Participant and Investigator Blinded
入排标准
- 年龄范围
- 18.00 Year(s) 至 60.00 Year(s)（—）
- 性别
- All
入选标准
- •Patient who will give written informed consent.
- •Scheduled for urgent or elective procedures requiring endotracheal anaesthesia.
- •Classified as American Society of Anaesthesiologists (ASA) physiccal status I to II.
- •Patients age between 18 and 60 years.
排除标准
- •1.Any contraindication or history of hypersensitivity to study drugs.
- •Presence of atrioventricular block of any degree.
- •History of cardiac arrhythmias or heart failure.
- •presence of kidney disease.
- •Body mass index(BMI)more than 25kgm2 6.Mallampatti grade 3 and 4 7.
结局指标
主要结局
To assess and compare the effect of intravenous lignocaine verus labetalol versus esmolol on haemodynamic parameters (HR,SBP,DBP,MAP) to laryngoscopy and endotracheal intubation.
时间窗: At 0,1,5 and 10 minutes after intubation.
次要结局
- To assess and compare proportion of patients developing any side effects.(Hypotension,Bradycardia,others)(At 0,1,5 and 10 minutes after intubation)
研究者
Dr Sunil Chauhan
SMS Medical College Jaipur