Changes in metabolome and epigenome after drastic weight loss and identification of novel forms of monogenetic obesity

• Conditions: Extreme ObesityGenetic disposition; E66; Obesity

• Registration Number: DRKS00011537
• Lead Sponsor: niversitätsklinikum Ulm für Kinder- und JugendmedizinSektion Pädiatrische Endokrinologie u. Diabetologie, Interdisziplinäre Adipositasambulanz

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Start: 2017-01-20
• Study Completion: 2021-09-30
• Last Update Posted: 19 August 2024

Recruitment & Eligibility

• Status: Complete
• Sex: All
• Target Recruitment: 107

Inclusion Criteria

Extreme Obesity

Exclusion Criteria

Subject do not want genetic analysis. Obesity is caused by underlying disease e.g. Brain tumor, Prader-Willi syndrome…

Study & Design

• Study Type: observational
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Changes in the metabolome and epigenome during lifestyle interventions. Therefore, we evaluate blood samples taken on the first and last day of long-term weight loss therapy. Blood samples are taken routinely before and after therapy.

Secondary Outcome Measures

Name	Time	Method
Comparison between good weight reducer” vs. low weight reducer” on the basis of weight development and metabolic/epigenetic parameters. Exclusion of underlying monogenetic causes of obesity by observation of weight development and metabolic parameter.