Multisensory perception in schizophrenia, A comparative study between healthy and schizophrenic individuals

Completed

Conditions: schizophrenia
10039628

Registration Number: NL-OMON35440

Lead Sponsor: niversiteit van Tilburg

Brief Summary: Not available

Detailed Description: Not available

Recruitment & Eligibility

Status: Completed

Sex: Not specified

Target Recruitment: 50

Inclusion Criteria

Inclusion criteria for all participants are:
(1) 18*55 years of age
(2) no history of electroconvulsive treatment
(3) no history of neurological illness
(4) no history of alcohol or drug dependence or abuse within the last year, or long duration (>1 year) of past abuse
(5) no medications which would grossly affect the EEG (e.g., barbiturates)
(6) normal hearing and normal or corrected-to-normal vision
(7) an ability and desire to cooperate with our experimental procedures as evinced by giving in-formed consent. ;Inclusion criteria for all schizophrenic participants are:
(8) Patients must meet DSM-IV-TR criteria for a diagnosis of schizophrenia by chart review and psychosis module M.I.N.I plus (Mini Internationaal Neuropsychiatrisch Interview). Severity is measured by the BPRS (Brief Psychiatric Rating Scale)
(9)Preferably monotherapy: atypical or classical antipsychotics without co-medication

Exclusion Criteria

Participants are excluded in case of known neurological disorders, head trauma, significant and habitual drug abuse or alcoholism in the last 12 months, mental retardation (i.e., premorbid IQ less than 75), or insufficient fluency in the Dutch language.

Study & Design

Study Type: Observational non invasive

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>The difference between schizophrenic patients and healthy volunteers with<br /><br>respect to the underlying mechanisms of multisensory integration. In Experiment<br /><br>2 the parameter is the audiovisual (McGurk) mismatch negativity. In Experiment<br /><br>2 the parameter is the auditory-evoked N1 component of the event-related<br /><br>potential by audiovisual integration. In Experiment 3 the parameter is the<br /><br>just noticeable difference for visual temporal order.</p><br>

Secondary Outcome Measures