Upside Down, Give me the Handle

Not Applicable

Completed

• Conditions: Schizophrenic Disorders
• Interventions: Other: cognitive tasks; Other: cognitive tasks + PANSS+ IQ

• Registration Number: NCT02544516
• Lead Sponsor: Centre Hospitalier Universitaire de Saint Etienne

Brief Summary

In schizophrenia, dislocation of psychic functions involving a loss of contact with reality is frequently found. A fragmentation of motor and sensory perceptions could be held responsible (Fuchs, 2005). However, automatic integration between perception and action is the necessary condition to be in "relationship with the world." Affordance is the experimental link between object perception and actions potentially associated (Gibson (1977, 1979) explored by Stimulus Response Compatibility (SRC) paradigm. The existence of visual motor neurons leads us to postulate that the affordance effect can be assisted by a visuomotor priming of a hand in a position to grasp. With Tucker \& Ellis sensory motor compatibility task, we study the capacity of affordance in schizophrenia, as well as the impact of perceptual motor priming on these affordance effects.

Detailed Description

All participants will perform cognitive tasks: reaction time (Alert TEA, Zimmermann and Fimm, 2005), Edinburgh laterality questionnaire (Oldfield, 1971), IQ test (IQ: PM38, Raven, 1960), and the PANSS (Positive and Negative Syndrome Scale, Kay et al., 1987). Controls will only have the first three tasks (cognitive spots Alert and laterality). Then all will perform all tasks in successive order (task 1 and task 2). For both tasks, photographs of 20 objects of everyday life typical grip with one hand are presented in 4 orientations. The instruction is to say if the object is presented upright or inverted; The second task differs from the first only by the introduction of a prime: presenting a hand in position "catching" before the picture of an object

Study Timeline

• Study Start: 2014-04
• Study First Submitted: 2015-09-07
• Study First Submitted QC: 2015-09-07
• Study First Posted: 2015-09-09
• Primary Completion: 2016-10
• Study Completion: 2016-10
• Status Verified: 2016-11
• Last Update Submitted: 2016-11-21
• Last Update Posted: 2016-11-22

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 60

Inclusion Criteria

For patients:

• a DSM-IV diagnosis of schizophrenia (men or women),
• no change in antipsychotic medication and clinical status within four weeks prior to the study

Exclusion Criteria

• IQ < 70

For patients and control group Inclusion criteria

• Age ≥ 18 years et ≤ 50 years

Exclusion Criteria:

• History of head trauma,
• neurological disease with cerebral repercussion or not stabilized serious physical illness;
• psychotropic medication,
• disorders related to the use of a psychoactive substance (abuse, dependence or withdrawal);

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
control group	cognitive tasks	healthy patients who will perform cognitive tasks
Patients	cognitive tasks + PANSS+ IQ	patients suffering schizophrenic disorders and who will perform cognitive tasks + PANSS+ IQ

Primary Outcome Measures

Name	Time	Method
response time	day 1	The gain provided by the compatible vs incompatible conditions (ms response time)

Trial Locations

Locations (1)

CHU de SAINT-ETIENNE; 🇫🇷 Saint-etienne, France