Links Between Perception of Temporal Order Judgment and Causality in Schizophrenia

Not Applicable

• Conditions: Schizophrenia
• Interventions: Other: Performances of patients and controls on temporal task

• Registration Number: NCT03432000
• Lead Sponsor: Hôpital le Vinatier

Brief Summary

People with schizophrenia show disturbances in the perception of time. Among these alterations are the perturbations of the temporal order judgment. They are characterized by the fact that, as opposed to the general population, people with schizophrenia require a longer time interval between two successive stimuli to estimate which of the two events appeared first. If these alterations are now well documented, their consequences remain little explored. Among these consequences could however appear distortions of the judgment of causality (likely to underlie certain delusional interpretations) as well as a distressing experience of loss of the continuity of the lived experience (that could contribute to the alterations basic of self-awareness).

Detailed Description

The objective of our work lies in the study of the links between temporal sequencing, subjective perception of time and causality.

To carry out this work, the investigators will rely on an experimental paradigm (derived from Michotte's paradigm) which makes it possible to explore the links between temporal sequencing and perception of causality, validated in the normal subject. subjective consequences of these alterations will be explored using a phenomenological-inspired clinical scale (EAWE time-scale items)

Study Timeline

• Study Start: 2018-02-01
• Study First Submitted: 2018-02-07
• Study First Submitted QC: 2018-02-12
• Study First Posted: 2018-02-13
• Status Verified: 2022-08
• Last Update Submitted: 2022-08-11
• Last Update Posted: 2022-08-12
• Primary Completion: 2022-09-30
• Study Completion: 2022-12-31

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: All
• Target Recruitment: 60

Inclusion Criteria

Subjects with schizophrenia:

• Age from 18 to 45 years
• Diagnosis of schizophrenia according to DSM V criteria
• French mother tongue
• Psychotropic treatment unchanged during the month preceding the inclusion
• Stable symptomatology
• Normal or corrected visual acuity (> 0.8 at Snellen scale) and normal color vision
• Patients who gave informed consent to participate in the study

Control subjects (healthy volunteers):

• Age from 18 to 45 years
• Absence of neurological and psychiatric disorders
• French mother tongue

Exclusion Criteria

• Recent addiction and abuse of cannabis or any other substance (according to DSM V criteria)
• Neurological disorders of vascular, infectious or neurodegenerative origin
• Taking somatic drugs with a cerebral or mental impact (eg corticosteroids)
• Disabling sensory disturbances, and in particular visual acuity
• Participation in a Neuro Cognitive Remediation Program
• Schizophrenia resistant to neuroleptic treatments
• Persons protected by law (pregnant women, minors, major under guardianship ...)

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
healthy subjects	Performances of patients and controls on temporal task	Evaluate the links (correlation) between perception of temporal sequencing and perception of causality using an adapted experimental paradigm (Michotte paradigm) and to compare performance between healthy subjects and controls Investigate the existence of a correlation between these alterations and the peculiarities of the subjective experience of time (EAWE scale) in the group of subjects with schizophrenia
subjects with schizophrenia	Performances of patients and controls on temporal task	Performances on temporal task Subjective alterations of time perception in patients with an adapted scale (EAWE) Global symptomatology with PANSS (positive and negative symptom scale)

Primary Outcome Measures

Name	Time	Method
Comparison of the scores obtained by subjects with schizophrenia vs. the controls for the causal tasks, according to the delays between stimuli (stopping the moving launcher and appearance of the static object).	eight months	Michotte paradigm: evaluate the links (correlation) between perception of temporal sequencing and perception of causality using an adapted experimental paradigm

Secondary Outcome Measures

Name	Time	Method
Comparisons of the scores obtained on the Time Experiment Rating Examination of Anomalous World Experience Scale (EAWE).	eight months	Examination of Anomalous World Experience (EAWE ) scale:investigate the existence of a correlation between these alterations and the peculiarities of the subjective experience of time The E.A.W.E. consists of 6 dimensions (relation to space / relation to time / relation to others / language / atmospheric experience / existential orientation).The second domain only will be explored in our study Each item is both detailed, on a scale of 0 to 2 (0 for absent, 1 for present but with doubt, 2 for present, no doubt). The overall score of the sub-time scale thus ranges between 0 and 78.

Trial Locations

Locations (1)

Vial Veronique; 🇫🇷 Bron, Rhone Alpes, France