Evaluation the Effect of Dietary Type on Oral Candida Carriage in Infants
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 90
- 试验地点
- 1
- 主要终点
- mean number of candida colonies
研究概览
简要总结
This is an observational, non-randomised trial to evaluate the effect of dietary type on infants oral candida colonization the investigators evaluated 90 infants in 1-24 months (45 breastfeeding and 45 bottle feeding infants) who attended to Yazd clinic for regular pediatric appointment. Infants with unremarkable health histories, normal weight, free of sign or symptom of oral candidiasis or other mucosal disease. Their mothers were also healthy and without sign or symptom of vagina or mammary candidiasis. Pacifier usage, use of antibiotics in last months, sign or symptom of oral candidiasis in infants or vagina and mammary candidiasis in mothers were exclusion criteria.
详细描述
After filling in a questionnaire about infants dietary intake, age and sex and their mothers education level and health condition, a pre-moistened sterile cotton swab was taken from dorsal surface of tongue and mid-plate. The swabs were cultured in agar plate containing sabourauds dextrose agar medium with chloramphenicol, and kept in 37 C for 48 hours. The number of candida colonies was counted and germ tube test performed to separate candida albicans from other types. The data was collected and analyzed by SPSS software and chi-square, logistic regression and mann-whitney test. Study hypothesis: feeding by mothers milk reduces oral candida colonization.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Retrospective
入排标准
- 年龄范围
- 1 Month 至 24 Months（Child）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •healthy infants
- •healthy mothers
排除标准
- •pacifier usage
- •use of antibiotics in last month
- •sign or symptom of oral candidiasis in infants
- •vagina and mammary candidiasis in mothers
结局指标
主要结局
mean number of candida colonies
时间窗: 6 months
number of candida colonies growth in agar plate
次要结局
- prevalence of oral candida colonization in infants according to age and sex(6 months)
研究者
Nastaran Azimi
Principal Investigator
Shahid Sadoughi University of Medical Sciences and Health Services