Elevated Levels of S-100B and Neuron-specific Enolase (NSE) in Spine Surgery: A Comparison of Serum Levels With Surgery for Long-bone Fractures
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Spinal Injury
- Sponsor
- Medical University of Vienna
- Enrollment
- 30
- Locations
- 1
- Primary Endpoint
- S-100B levels
- Status
- Completed
- Last Updated
- 12 years ago
Overview
Brief Summary
The hypothesis of this study is to find evidence if there is an influence of spine surgery on the serum levels of two proteins secreted from neuronal cells.
Detailed Description
The question, if there is an effect on the cerebrospinal system during spine surgery, which can be traced by monitoring serum levels of neuromarkers is not yet answered. This study has its background from other studies on patients with traumatic brain injury (TBI), in whom elevated serum levels of the two neuromarkers S-100B and NSE are associated with injury severity, neuronal damage, brain, tissue damage, and outcome. Patients undergoing spine surgery with or without pre-existing traumatic neurologic symptoms are planned to be the study cohort. Pre- and postoperatively the serum levels of S-100B and NSE are obtained and are statistically compared with patients undergoing other types of bone-related surgery.
Investigators
Harald Wolf, MD
Dr. Harald Wolf
Medical University of Vienna
Eligibility Criteria
Inclusion Criteria
- •spine fracture
Exclusion Criteria
- •additional traumatic brain injury
- •fractures of the long bones
- •polytrauma
- •severely injured patients
Outcomes
Primary Outcomes
S-100B levels
Time Frame: 4 hours
average timeframe between blood withdrawal (twice, pre-and post-operatively)