NCT01458938终止不适用
Substance P Neuropeptide Levels in Saliva, Serum and Cerebrospinal Fluid in Patients With Spinal Disease: A Pilot Study
适应症
试验速览
- 阶段
- 不适用
- 状态
- 终止
- 入组人数
- 53
- 试验地点
- 1
- 主要终点
- Substance P Neuropeptide Levels in Saliva And Serum in Patients with Spinal Disease: A Pilot Study
研究概览
简要总结
The objective of this pilot study is to determine if degenerative spinal disorders such as acute radiculopathy, myelopathy, stenosis, or disc and facet disease cause detectable alterations in Substance P levels in saliva, serum and cerebrospinal fluid. If this pilot study shows a correlation between Substance P levels and pain associated with degenerative spinal disorders, then a larger study will be initiated to determine the feasibility of using Substance P levels in the diagnosis and treatment of degenerative spinal disease.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 65 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Undergoing spinal surgery for medically refractory spinal radiculopathy,
- •myelopathy or neurogenic claudication based on either history, physical examination or radiologic studies demonstrating neural compression or degenerative disc disease.
- •Undergoing surgery for medically refractory axial spinal pain.
排除标准
- •Previous spinal procedures or operations,
- •radicular pain,
- •history of fibromyalgia,
- •chronic pain,
- •rheumatoid arthritis,
- •autoimmune disorders,
- •Major Depressive Disorder,
- •migraine headaches or active rhinosinusitis,
- •nicotine intake
结局指标
主要结局
Substance P Neuropeptide Levels in Saliva And Serum in Patients with Spinal Disease: A Pilot Study
时间窗: 2009-2014
Study was closed pending re-design at some future date to improve efficacy.
次要结局
未报告次要终点
研究者
研究点 (1)
Loading locations...
相似试验
终止
不适用
Measurement of Substance P in Saliva of Low Back Pain PatientsLow Back PainNCT00735735Kovacs Foundation40
已完成
不适用
A Pilot Study to Identify Biomarkers Associated With Chronic Traumatic Brain InjuryTraumatic Brain InjuryNCT01171131The University of Texas Health Science Center, Houston96
已完成
不适用
Neuromarker S-100B as Diagnostic ToolSpinal InjuryNCT01840397Medical University of Vienna30
已完成
不适用
rTMS-induced Cumulative Pattern of sBDNF in Chronic SchizophreniaSchizophreniaNCT01427088Jeonbuk Provincial Maeumsarang Hospital21
已完成
3 期
Treatment of Peripheral Neuropathy in Patients With DiabetesDiabetic NeuropathiesDiabetes MellitusNCT00044421Eli Lilly and Company400