PET/MRI Imaging of Neuraxial Inflammation in Sciatica Patients
Overview
- Phase
- Not Applicable
- Intervention
- Radioactive dye
- Conditions
- Sciatica
- Sponsor
- Massachusetts General Hospital
- Enrollment
- 42
- Locations
- 1
- Primary Endpoint
- Inflammation in the spine
- Status
- Completed
- Last Updated
- 6 years ago
Overview
Brief Summary
The purpose of this study is to see if the spine shows areas of inflammation using a specific type of imaging (pictures).
Detailed Description
The purpose of this study is to determine if inflammation around the spinal nerves can be identified using a radioactive tracer \[11C\] PBR28 and integrated PET/MRI scan for the purpose of better treating patients who have radicular lumbar pain with epidural steroid injections.
Investigators
Yi Zhang, MD
Principal Investigator
Massachusetts General Hospital
Eligibility Criteria
Inclusion Criteria
- Not provided
Exclusion Criteria
- Not provided
Arms & Interventions
Healthy
Healthy subjects with no pain. * Radioactive dye * PET/MRI * Blood draw
Intervention: Radioactive dye
Healthy
Healthy subjects with no pain. * Radioactive dye * PET/MRI * Blood draw
Intervention: PET/MRI
Healthy
Healthy subjects with no pain. * Radioactive dye * PET/MRI * Blood draw
Intervention: Blood draw
Sciatica
Subjects with sciatica and scheduled for an epidural steroid injection (ESI). * Radioactive dye * PET/MRI * Blood draw
Intervention: Radioactive dye
Sciatica
Subjects with sciatica and scheduled for an epidural steroid injection (ESI). * Radioactive dye * PET/MRI * Blood draw
Intervention: PET/MRI
Sciatica
Subjects with sciatica and scheduled for an epidural steroid injection (ESI). * Radioactive dye * PET/MRI * Blood draw
Intervention: Blood draw
Outcomes
Primary Outcomes
Inflammation in the spine
Time Frame: 2 hours
The presence of inflammation in the spine using the radioactive tracer \[11C\]PBR28.
Secondary Outcomes
- Pain Scores on the Visual Analog Scale (VAS)(up to 3 months)