Neuronal and Behavioral Effects of an Implicit Priming Approach to Improve Eating Behaviors in Obesity
Trial Snapshot
- Phase
- Not Applicable
- Status
- Recruiting
- Enrollment
- 228
- Locations
- 1
- Primary Endpoint
- Percent Change in Blood Oxygen Level Dependent (BOLD) Response to Visual Food Cues as Measured by Functional Magnetic Resonance Imaging
Study Overview
Brief Summary
The purpose of this study is to determine how different behavioral interventions designed to alter food perceptions and behaviors affect brain responses to food, eating behaviors, and body weight.
Study Design
- Study Type
- Interventional
- Allocation
- Randomized
- Intervention Model
- Parallel
- Primary Purpose
- Other
- Masking
- Triple (Participant, Investigator, Outcomes Assessor)
Eligibility Criteria
- Ages
- 18 Years to 65 Years (Adult, Older Adult)
- Sex
- All
- Accepts Healthy Volunteers
- Yes
Inclusion Criteria
- •18-65 years old
- •BMI of 27 or greater
Exclusion Criteria
- •MRI contraindications (e.g., metal or electronic devices in the body)
- •Pregnancy
Arms & Interventions
Active Implicit Priming
Participants will complete active implicit priming, in which food images are implicitly primed (i.e., below conscious awareness) with images of positive or negative affect. This will be completed on a weekly basis for 12 weeks, for approximately 10 minutes each time.
Intervention: Active Implicit Priming (Behavioral)
Control Implicit Priming
Participants will complete control implicit priming, which matches the active intervention, but with neutral stimuli as primes. This will be completed on a weekly basis for 12 weeks, for approximately 10 minutes each time.
Intervention: Control Implicit Priming (Behavioral)
Food Exposure Task
Participants will complete a Food Exposure Task, in which they will be asked to smell, feel, lick, and imagine eating food items, but without actually eating them. This will be completed on a weekly basis for 12 weeks, for approximately 10-30 minutes each time.
Intervention: Food Exposure Task (Behavioral)
Outcomes
Primary Outcomes
Percent Change in Blood Oxygen Level Dependent (BOLD) Response to Visual Food Cues as Measured by Functional Magnetic Resonance Imaging
Time Frame: Baseline, 12 weeks
Percent change in blood oxygen level dependent (BOLD) response from baseline to after the 12-week intervention while viewing visual food cues will be measured using functional magnetic resonance imaging (fMRI), focusing on insula, striatum, and prefrontal cortex.
Change in Food Image Ratings
Time Frame: Baseline, 12 weeks
Food image ratings change from baseline to after the 12-week intervention. Food images are rated on "desire to eat" by visual analogue scale (0-100), with higher scores indicating greater desire to eat.
Change in Food Intake
Time Frame: Baseline, 12 weeks
Food intake change from baseline to after the 12-week intervention. Food intake will be measured as total calories consumed during an ad libitum meal.
Secondary Outcomes
- Percent Change in Body Weight(Baseline, 12 weeks)
- Change in Fat Mass(Baseline, 12 weeks)