Role Of Human Papilloma Virus In Male Infertility In Qena Government - Upper Egypt
Trial Snapshot
- Phase
- Not Applicable
- Status
- Completed
- Sponsor
- South Valley University
- Enrollment
- 50
- Locations
- 1
- Primary Endpoint
- Investigation of Human Papilloma Virus infection in infertile males
Study Overview
Brief Summary
Infertility is a major health problem worldwide and is estimated to affect 8-12% of couples in the reproductive age group.
Infertility affects both men and women. Male causes for infertility are found in 50% of these couples.
HPV may infect the semen ,allowing it to affect male fertility in a variety of ways.
Detailed Description
WHO defines infertility as the inability to conceive after at least 12 months of regular, unprotected sexual intercourse.
Reduced male fertility can be the result of congenital and acquired urogenital abnormalities, infections of the male accessory glands, increased scrotal temperature (varicocele), endocrine disturbances, genetic abnormalities and immunological factors ,
In 40-60% of cases the only abnormality is the semen analysis and there is no relevant history or abnormality on physical examination and endocrine laboratory testing (idiopathic male infertility).
Semen analysis reveals a decreased number of spermatozoa (oligozoospermia), decreased motility (asthenozoospermia) and many abnormal forms on morphological examination (teratozoospermia). Usually, these abnormalities come together and are described as the OAT-syndrome (oligo-astheno-teratozoospermia).
Human papillomavirus (HPV) is one of the most common sexually transmitted viruses, and males and females from different regions are generally susceptible.
Study Design
- Study Type
- Observational
- Observational Model
- Case Control
- Time Perspective
- Cross Sectional
Eligibility Criteria
- Ages
- 23 Years to 53 Years (Adult)
- Sex
- Male
- Accepts Healthy Volunteers
- Yes
Inclusion Criteria
- •Patients with at least 1 year of unprotected sexual intercourse without conception.
- •Patients with genital warts
Exclusion Criteria
- •Hypergonadotropic/hypogonadotropic hypogonadism
- •Azoospermia
- •chromosome abnormalities
- •undescended testis
- •mumps orchitis
Outcomes
Primary Outcomes
Investigation of Human Papilloma Virus infection in infertile males
Time Frame: 2 Days
Investigation of Human Papilloma Virus (HPV) infection in infertile males as : all participants in the study made semen analysis and the semen were collected by masturbation after 5-7 days of abstinence. Semen parameters (semen volume, sperm concentration, progressive motility (PR) and rate of normal sperm morphology) were analyzed in a thermostat console after semen liquefaction. then Seminal Detection of HPV antibodies in infertile male by HPV ELISA Kit and also to see its effects on semen parameters in Qena government.
Secondary Outcomes
No secondary outcomes reported
Investigators
Mohammed Abderlraheem Abdellatif
Resident at Dermatology , venereology and andrology, Faculty of medicine
South Valley University