The Factors Causing Treatment Failure in Children Receiving Oxygen Therapy With High-flow Nasal Cannula

Completed

• Conditions: Respiratory Distress; Treatment Failure; High-flow Nasal Cannula

• Registration Number: NCT06146439
• Lead Sponsor: Dr. Behcet Uz Children's Hospital

Brief Summary

The goal of this observational study is to identify the variables that predict treatment failure in order to identify the patients in which HFNC treatment may fail and not delay the transition to advanced respiratory support treatments in these patients.

The main questions it aims to answer are:

* What factors contribute to the failure of HFNC treatment in these children?

* What is the frequency of HFNC treatment failure in children with moderate and severe respiratory distress? Researchers will compare the group whose HFNC treatment was successful with the group whose HFNC treatment failed to identify factors that cause treatment failure.

Detailed Description

Oxygen therapy with a high-flow nasal cannula (HFNC) is a well-tolerated, relatively new, non-invasive alternative ventilation treatment modality. On the other hand, HFNC failure delays advanced respirator supportive treatments, prolongs hospitalization in the intensive care unit, and emergency department, and causes a significant increase in morbidity and mortality with hypoxemia, neurological impairment, and/or hemodynamic instability. The investigators aimed to identify the variables that predict treatment failure in order to identify the patients in which HFNC treatment may fail and not delay the transition to advanced respiratory support treatments in these patients.

Study Timeline

• Study Start: 2018-10-01
• Primary Completion: 2020-01-01
• Study Completion: 2020-02-01
• Status Verified: 2023-11
• Study First Submitted: 2023-11-19
• Study First Submitted QC: 2023-11-19
• Study First Posted: 2023-11-24
• Last Update Submitted: 2023-11-24
• Last Update Posted: 2023-11-29

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 201

Inclusion Criteria

• Moderate to severe respiratory distress
• Oxygen therapy with high-flow nasal cannula

Exclusion Criteria

• Chronic lung disease (those with CO2 retention or hypoxia in their daily life)
• Cyanotic congenital heart disease
• Craniofacial malformation
• Trauma patients
• Hypotonic patients
• Cases with tracheostomy
• Patients using HFNC therapy for respiratory support after extubation

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
HFNC treatment outcome (failure or success)	30 days	Whether advanced respiratory support treatments (invasive and noninvasive mechanical ventilation) are needed

Trial Locations

Locations (1)

Dr Behcet Uz Children's Hospital; 🇹🇷 İzmir, Turkey