Comparison in frequency of hypotension during perioperative period for sedation of dexmedetomidine and remimazolam in patients undergoing spinal anesthesia for low extremity surgery: a randomized controlled clinical trial
- Conditions
- Diseases of the musculoskeletal system and connective tissue
- Registration Number
- KCT0007138
- Lead Sponsor
- Asan Medical Center
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- ot yet recruiting
- Sex
- All
- Target Recruitment
- 74
1) Patients aged 20 to 80 years
2) Patients scheduled for regular schedule and receiving spinal anesthesia for lower extremity surgery
3) ASA physical status 1-3
4) Patients who voluntarily consented in writing to participate in this clinical trial
1) Patients who do not consent to study participation
2) Patients with adverse reactions to bupivacaine, dexmedetomidine, remimazolam, phenylephrine, nicardipine, esmolol, or atropine
3) Patients planned not to be sedated during surgery
4) Patients with uncontrolled medical or psychiatric problems
5) Pregnant or lactating patients
6) Patients whose spinal anesthesia range is greater than T8
7) Patients who are judged unsuitable for participation by medical staff for other reasons
Study & Design
- Study Type
- Interventional Study
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Frequency of hypotensive episodes in two groups (patients using dexmedetomidine or remimazolam) who underwent spinal anesthesia for lower extremity surgery
- Secondary Outcome Measures
Name Time Method Total dose of vasopressors (ephedrine, phenylephrine) administered ;Total amount of fluid;Frequency of hypertensive episodes per hour;Postoperative complications (cardiovascular, neurological, respiratory, delirium, renal function decline, postoperative nausea, vomiting, etc.);sedation score