efficacy and safety of allergen extract dropping therapy for severe peanut and nut (walnut) allergy
Not Applicable
Recruiting
- Conditions
- food allergy
- Registration Number
- JPRN-UMIN000048007
- Lead Sponsor
- Yokohama Nishikage Clinic: kids and allergies
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Recruiting
- Sex
- All
- Target Recruitment
- 20
Inclusion Criteria
Not provided
Exclusion Criteria
the subjects who have the conditions bellow 1.poorly controlled atopic dermatitis 2.poorly controlled asthma 3.immunodeficiency 4.taking beta blockers 5. pregnancy 6. taking medications for psychiatric disorders except child developmental disorders 7.malignant diseases
Study & Design
- Study Type
- Observational
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method the rate of the subjects who could have been administered a usual oral immunotherapy using peanut or nut(walnut) powder in mg unit during the test period.
- Secondary Outcome Measures
Name Time Method 1.oral challenge threshold changes of serially diluted allergen extracts; verified every month till 24 months after the research start. 2. oral challenge threshold changes of antigen powders in mg units.(every month) 3.threshold changes of skin prick tests of serially diluted allergen extracts.(every year) 4. changes of wheel size of skin prick tests of diluted allergen extracts.( every year) 5. antigen specific IgE level change (every year) 6.Basophil Activation Test results on several diluted allergen extracts(before and after the study) 7.the rate of subjects who could intake allergen nut containing foods. 8.safety evaluation (the rate of adverse reactions at challenge phases in a clinic setting and maintenance phases at home)