Effect of Recruitment Maneuvers Plus Optimal PEEP Versus Optimal PEEP Alone in One Lung Ventilation
Not Applicable
Completed
- Conditions
- Mechanical Ventilation Complication
- Registration Number
- NCT03635281
- Lead Sponsor
- Università degli Studi di Ferrara
- Brief Summary
The intraoperative driving pressure (∆P) has been recently identified as the greater independent predictor of postoperative pulmonary complications after one lung ventilation (OLV). The application of a positive end-expiratory pressure (PEEP) level of 5 or 10 cmH2O has been shown to reduce the ∆P and the V/Q mismatch (Spadaro 2017); however, the "optimal" PEEP level able to minimize the ∆P may change significantly across patients. The aim of this study is to describe the optimal PEEP levels in patients undergoing thoracic surgery
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 60
Inclusion Criteria
• Patients undergoing VATS with OLV ≥2 hours
Exclusion Criteria
- ASA (American Society of Anesthesiologists Physical Status Classification) score ≥ 4
- severe chronic respiratory failure (chronic obstructive pulmonary disease patients with GOLD stage 3 or 4
- preoperative hemoglobin less than 10 g ml-1
- hemodynamic instability (defined as a decrease in systolic arterial pressure of more than 20% from baseline),
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Primary Outcome Measures
Name Time Method pulmonary shunt, expressed as percentage, measured by ALPE system 20 minutes after intervention
- Secondary Outcome Measures
Name Time Method intraoperative driving pressure, measured as plateau pressure - PEEP 20 minutes after intervention
Trial Locations
- Locations (1)
Università di Ferrara
🇮🇹Ferrara, Italy
Università di Ferrara🇮🇹Ferrara, Italy