NCT07201649招募中不适用
Roles of Hepatic Insufficiency, Hepatic Fibrosis, and Inorganic Pyrophosphate in the Progression of Arterial Calcifications
适应症
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 入组人数
- 95
- 试验地点
- 2
- 主要终点
- hepatic transplantation reduces arterial calcification
研究概览
简要总结
Individuals with metabolic syndrome (MetS), particularly those with type 2 diabetes (T2D), and/or metabolic dysfunction-associated steatohepatitis or MASH face an elevated risk of major cardiovascular events (MACE). We showed decrease plams level of PPi in patients with liver cirrhosis. We hypothezised that liver transplant should block AC and restore PPi plasma level.
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Diagnostic
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •everyone requiring liver transplantation for the treatment of a chronic liver disease
排除标准
- •MELD score >25, viral replication
结局指标
主要结局
hepatic transplantation reduces arterial calcification
时间窗: On the 7th day after surgery
compare the percent of patients with AC progression before and after liver tranplantation
次要结局
- increase of PPi plasma level after liver transplantation(at inclusion and at 3 months)
- identify arterial calcification related factors(On the 7th day after surgery)
研究者
研究点 (2)
Loading locations...
相似试验
已完成
不适用
Changes in Intrahepatic Lipids With ExerciseObeseNCT02181270University of Missouri-Columbia57
已完成
不适用
Prospective Cohort Study of Association of Insulin Resistance/Steatosis With Hepatic Fibrosis in CHB and NAFLDChronic Hepatitis BFatty LiverHepatic FibrosisNCT02031913Seoul National University Boramae Hospital500
已完成
不适用
Relationship of Metabolic Abnormalities to Hepatic Steatosis in HIVSteatohepatitisNCT00575757Virginia Commonwealth University12
招募中
不适用
Liver Enzymes and Metabolic Risk Factors Response to Laser Acupuncture Versus Cupping Therapy in Fatty LiverFatty LiverNCT05623930Cairo University60
招募中
不适用
The effect of metabolic syndrome and associated genetic factors on fatty liver diseaseon alcoholic fatty liver diseaseJPRN-UMIN000027399Kyoto Prefectural University of Medicine3,000