Role of MSCT of Chest in Differentiation Between COPD Patients According to Their Smoking Status

• Conditions: Patient Participation
• Interventions: Diagnostic Test: MSCT chest

• Registration Number: NCT05475977
• Lead Sponsor: Somaia Ahmad AbdAllah Ahmad

Brief Summary

Chronic obstructive pulmonary disease (COPD) is a major cause of morbidity and mortality all over the world. Smoking is considered as an important risk factor, but other risk factors are present. Around 30 % of patients with COPD are non-smokers.

Cessation of smoking in patients with COPD causes decreases the presence of micronodules and other criteria of CT chest.

In last few years, some researchers reported that cessation of smoking raise the apparent extent of emphysema. The cause is not obvious, but this paradoxical fall in lung density is thaught to be resulting from decrease in inflammation after smoking cessation.

CT chest criteria of COPD in active smokers, non-smokers and ex-smokers seem to be different.

So, comparison between CT chest Criteria of COPD in smokers, ex-smokers and non-smokers will be searched in this study to detect the role of multislice computed tomography (MSCT) chest in differentiation between COPD patients according to their smoking status.

Detailed Description

Basic ethical principles of medical research; beneficence (do well), non-maleficence (do no harm), respect and distributive justice were implemented. The study will be carried out in accordance with the Declaration of Helsinki and the principles of good clinical practice.

Study Timeline

• Study First Submitted: 2022-06-28
• Study First Submitted QC: 2022-07-26
• Study First Posted: 2022-07-27
• Status Verified: 2022-08
• Study Start: 2022-08
• Last Update Submitted: 2022-08-01
• Last Update Posted: 2022-08-02
• Primary Completion: 2023-04
• Study Completion: 2023-07

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: All
• Target Recruitment: 90

Inclusion Criteria

1. All patients with chronic obstructive Pulmonary Disease.
2. Patients above 18 years.

Exclusion Criteria

1. Patients with unclear smoking history.
2. Patients with active pneumonia.
3. Patients with acute COPD exacerbation.

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
Second group	MSCT chest	Thirty patients of COPD ex-smokers patients.
Third group	MSCT chest	Thirty patients of COPD non-smokers patients.
First Group	MSCT chest	Thirty patients of COPD smokers patients.

Primary Outcome Measures

Name	Time	Method
Number of participants with criteria of severe COPD	18 months	Criteria of severe COPD include emphysematous bullae, thick bronchial walls.