Effects of fish oil and coenzyme Q10 on cardiovascular risk in chronic renal failure
Completed
- Conditions
- Patients with mild renal impairmentRenal and Urogenital - Other renal and urogenital disorders
- Registration Number
- ACTRN12605000088640
- Lead Sponsor
- Dr Trevor A Mori
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- All
- Target Recruitment
- 120
Inclusion Criteria
Evidence of impaired GFR (>20 and <80 ml/min), serum creatinine <350umol/L and haemoglobin >110g/L. Patients receiving antihypertensive or lipid-lowering medication will not be excluded.
Exclusion Criteria
Angina pectoris; major surgery, a cardiovascular event or diagnosis of symptoms < 3 months; BP >170/100mmHg; diabetes; liver disease; current smokers; regular non-steroidal anti-inflammatory drug therapy; eating > 1 fish meal / week or regularly taking fish oil supplements; and consuming an average > 4 standard alcoholic drinks / day.
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method To determine whether a combined approach including fish oil supplementation and coenzyme-Q10 (CoQ) has additive effects in improving blood pressure, vascular function and arterial compliance. A beneficial alteration of the serum lipid profile is also anticipated. [Measurements will be performed during the last week of baseline and the last week of intervention.]
- Secondary Outcome Measures
Name Time Method