Effect of combined fish oil and coenzyme Q10 supplementation on liver fat composition, liver fat content and cardiovascular risk factors in overweight me

Not Applicable

Completed

• Conditions: hepatic steatosis; Metabolic and Endocrine - Other metabolic disorders; Oral and Gastrointestinal - Other diseases of the mouth, teeth, oesophagus, digestive system including liver and colon

• Registration Number: ACTRN12610000351011
• Lead Sponsor: niversity of Sydney

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2010-05-03
• Last Update Posted: 13 January 2020

Recruitment & Eligibility

• Status: Completed
• Sex: Male
• Target Recruitment: 50

Inclusion Criteria

Overweight men: body mass index (BMI) greater than 25 but less than 30 with a waist circumference greater than or equal to 94cm.

Exclusion Criteria

history of heart, lung or kidney disease; smoking and excess alcohol consumption; known allergy to fish or other seafood; a haemorrhagic disorder, or receiving anticoagulants and/or other drugs affecting coagulation; hepatic impairment (i.e., severe liver enzyme elevation); supplements or medications known to affect outcome measures.

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Hepatic triglyceride concentration (measured by localised proton magnetic resonance spectroscopy)[Baseline, 6 weeks, 12 weeks.]

Secondary Outcome Measures

Name	Time	Method
Hepatic triglyceride composition (magnetic resonance spectroscopy)[Baseline, 6 weeks, 12 weeks.];visceral adiposity (magnetic resonance imaging)[Baseline, 6 weeks, 12 weeks.];fasting plasma triglycerides (blood analysis)[Baseline, 6 weeks, 12 weeks.];cholesterol (blood analysis)[Baseline, 6 weeks, 12 weeks.];High Density Lipoprotein-cholesterol (blood analysis)[Baseline, 6 weeks, 12 weeks.];Apolipoprotein A-I (blood analysis)[Baseline, 6 weeks, 12 weeks.];serum biochemistry (blood analysis)[Baseline, 6 weeks, 12 weeks.];insulin (blood analysis)[Baseline, 6 weeks, 12 weeks.];Glycated haemoglobin (HbA1c) (blood analysis)[Baseline, 6 weeks, 12 weeks.];Plasma adiponectin (blood analysis)[Baseline, 6 weeks, 12 weeks.];High-sensitivity C-reactive protein (blood analysis)[Baseline, 6 weeks, 12 weeks.];Fasting liver enzymes (alanine aminotransferase, ALT; aspartate aminotransferase, AST; gamma-glutamyl transferase GGT) (blood analysis)[baseline, 6 weeks, 12 weeks]