se of noninvasive monitoring along with clinical monitoring for need of fluid bolus in pediatric septic shock
Not Applicable
- Conditions
- Health Condition 1: R652- Severe sepsis
- Registration Number
- CTRI/2022/03/041366
- Lead Sponsor
- Suman Sudha Moharana
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Open to Recruitment
- Sex
- Not specified
- Target Recruitment
- 0
Inclusion Criteria
Children aged 2 months to 18 years with septic shock,defined as children with suspect or confirmed sepsis & unresolved shock/hypoperfusion after initial 10 ml/kg fluid bolus
Exclusion Criteria
Children with fulminant Myocarditis
Children with unrepaired congenital heart disease
Post arrest cardiac dysfunction & shock
Children with Severe acute malnutrition
Children with chronic kidney disese
Moribound patients with anticipated survival <24 hours
Not willing to participate in study
Children who received fluid bolus in outside facility
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method To Evaluate the difference in fluid volume requirement in first 6 hours between two groupsTimepoint: 6 hours
- Secondary Outcome Measures
Name Time Method Proportion of children achieving shock resolution at 6 12 24 48 and 72 hours of resuscitation <br/ ><br>Vasoactive-inotrope score at 6 12 24 48 and 72 hours <br/ ><br>Fluid overload percent at 24 48 and 72 hours <br/ ><br>Organ dysfunction scores pSOFA and PELOD2 and severity of illness score PRISM at 24 48 and 72 hours <br/ ><br>Need for and duration of mechanical ventilation <br/ ><br>Need for RRT within 28 days <br/ ><br>Length of PICU stay and hospital stay <br/ ><br>Early within 7 days and late 7 to 28 day mortality <br/ ><br>Timepoint: 6 hour <br/ ><br>12 hour <br/ ><br>24 hour <br/ ><br>72 hour