Metabolomic Alterations in the Vascular Compartment in Patients With Sepsis
Terminated
- Conditions
- Endothelial Dysfunction
- Registration Number
- NCT03655899
- Lead Sponsor
- Pär Johansson
- Brief Summary
This study will investigate the metabolic alterations of vascular cells caused by sepsis and septic shock
- Detailed Description
This study will investigate the metabolic alterations of vascular cells caused by sepsis and septic shock in 60 patients
Recruitment & Eligibility
- Status
- TERMINATED
- Sex
- All
- Target Recruitment
- 37
Inclusion Criteria
- 18 year or older
- Sepsis or Septic shock
Exclusion Criteria
- Pregnant or breastfeeding
- Hemoglobin ≤ 5.0 mmol/L
- Platelets ≤ 5.0 mia/L
- Consent not obtainable
- Do not resuscitate order
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Shock induced endotheliopaty Up to 30 days Mortality
- Secondary Outcome Measures
Name Time Method
Related Research Topics
Explore scientific publications, clinical data analysis, treatment approaches, and expert-compiled information related to the mechanisms and outcomes of this trial. Click any topic for comprehensive research insights.
What metabolic pathways in vascular cells are altered in sepsis-induced endothelial dysfunction?
Which metabolomic biomarkers predict severity or response to treatment in septic shock patients?
How do vascular compartment metabolomic changes correlate with sepsis complications like DIC or ARDS?
What existing drug classes target altered metabolic pathways in sepsis-associated endothelial dysfunction?
How do NCT03655899 findings compare to other observational studies on sepsis metabolomics?
Trial Locations
- Locations (1)
Bispebjerg Hospital
🇩🇰Copenhagen, Copenhagen NV, Denmark
Bispebjerg Hospital🇩🇰Copenhagen, Copenhagen NV, Denmark