Correlation Between Expression of Hormonal Receptors, Clinical Data, and Methylation Profile in Meningiomas
试验速览
- 阶段
- 不适用
- 状态
- Enrolling By Invitation
- 发起方
- 入组人数
- 180
- 主要终点
- immunohistochemical expression of different hormonal receptors
研究概览
简要总结
This research aims to explore the relationship between hormonal receptor expression and the clinical and histopathological characteristics of meningiomas. The underlying hypothesis is that hormonal receptor expression, as well as the methylation profile of their gene promoters, are associated with specific aspects of meningiomas and patients' clinical outcomes. The main objective is to study the correlation between the immunohistochemical expression of hormonal receptors and clinicopathological data. The secondary objectif is to study the correlation between the methylation profile of hormonal receptor gene promoters and their immunohistochemical expression.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Other
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Patients who underwent surgery for a meningioma at the University Hospital of Nancy between 2000 and 2022.
排除标准
- •Patients who did not express their consent to participate in the study.
- •Patients with grade 2 or 3 meningiomas whose samples are no longer available or in insufficient quantity to perform an immunohistochemical study.
- •Patients with grade 1 meningiomas not selected by randomization.
- •Patients withdrawing their consent.
结局指标
主要结局
immunohistochemical expression of different hormonal receptors
时间窗: up to 24 years after surgery
Evaluated on FFPE sections
次要结局
- methylation profile of the promoters of hormonal receptor genes(up to 24 years after surgery)
研究者
Guillaume GAUCHOTTE
Professor
Central Hospital, Nancy, France