Effects of Silybum Marianum on Treatment of Patients With Chronic Hepatitis C
- Registration Number
- NCT01292161
- Lead Sponsor
- Isfahan University of Medical Sciences
- Brief Summary
The purpose of this study is to determine the effects of silymarin on outcomes of patients with hepatitis C.
- Detailed Description
Silymarin has been claimed to have a beneficial effect in various types of liver injury, including alcoholic liver disease, drug and toxin induced hepatotoxicity, and acute and chronic viral hepatitis.
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 55
confirmed chronic hepatitis C (HCV Ab (+), HCV RNA (with PCR) (+)) normal or increased liver enzymes (ALT and AST) not using interferon or ribavirin due to patient sensitivity or not consenting.
The pregnant patients patients with side effect which confirmed with rechallenge test
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- SINGLE_GROUP
- Arm && Interventions
Group Intervention Description Silymarin Silymarin Silymarin drived from Silybum marianum (milk thistle), a flowering member of the daisy family, may benefit liver function in people infected with the hepatitis C virus.
- Primary Outcome Measures
Name Time Method Serum aminotransferases (ALT, AST) at six months after admission The investigators measured serum amino transferases by commercial AST kit,. ALT kits(Bayer Diagnostics,. Tarrytown, NY, USA) at six months after silymarin admission
- Secondary Outcome Measures
Name Time Method HCV-RNA at six months after admission The investigators measured serum HCV-RNA by Polymerase Chain Reaction (PCR) at six months after silymarin admission
Trial Locations
- Locations (1)
Al-zahra university hospital
🇮🇷Isfahan, Iran, Islamic Republic of