Effects of Using Miswak in Addition to Oral Hygiene Products in Patients With Gingivitis
试验速览
- 阶段
- 不适用
- 状态
- 尚未招募
- 入组人数
- 36
- 试验地点
- 2
- 主要终点
- Change in Salivary Interleukin-1 Beta (IL-1β) Levels
研究概览
简要总结
This pilot study aims to evaluate the effects of miswak use on the oral biological environment by comparing biochemical parameters obtained from saliva and dental plaque samples collected from individuals who use miswak and controls. A total of 36 healthy volunteers will be enrolled in the study, including 18 miswak+rutine oral hygiene products users and 18 rutine oral hygiene products.
Periodontal clinical parameters will be recorded, and saliva and supragingival dental plaque samples will be collected from all participants. The collected samples will be analysed for biomarkers associated with periodontal inflammation and oxidative stress. Interleukin-1 beta (IL-1β), C-reactive protein (CRP), and oxidative stress levels will be measured using biochemical analysis.
The findings of this study are expected to provide preliminary evidence regarding the biological effects of miswak on oral health and contribute to the current understanding of its potential role as an adjunctive oral hygiene tool.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 60 Years(Adult)
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •To be in the age range of 18-60 years
- •To have no systemic disease
- •To be diagnosed with gingivitis
排除标准
- •History of recent periodontal treatment
结局指标
主要结局
Change in Salivary Interleukin-1 Beta (IL-1β) Levels
时间窗: Pre-op 4 weeks and after 6 weeks
To evaluate the effect of adjunctive miswak use on salivary interleukin-1 beta (IL-1β) levels in patients with gingivitis. Salivary IL-1β concentrations will be measured using enzyme-linked immunosorbent assay (ELISA).
次要结局
- Change in Clinical Periodontal Indices(Pre-op 4 weeks and after 6 weeks)
- Change in Salivary C-Reactive Protein (CRP) Levels(Pre-op 4 weeks and after 6 weeks)
- Change in Salivary Oxidative Stress Levels(Pre-op 4 weeks and after 6 weeks)
研究者
Aysegul SARI
Assoc Prof
Mustafa Kemal University
