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临床试验/NCT07689786
NCT07689786尚未招募不适用

Effects of Using Miswak in Addition to Oral Hygiene Products in Patients With Gingivitis

Mustafa Kemal University2 个研究点 分布在 1 个国家目标入组 36 人开始时间: 2026年7月4日最近更新:
适应症

试验速览

阶段
不适用
状态
尚未招募
入组人数
36
试验地点
2
主要终点
Change in Salivary Interleukin-1 Beta (IL-1β) Levels

研究概览

简要总结

This pilot study aims to evaluate the effects of miswak use on the oral biological environment by comparing biochemical parameters obtained from saliva and dental plaque samples collected from individuals who use miswak and controls. A total of 36 healthy volunteers will be enrolled in the study, including 18 miswak+rutine oral hygiene products users and 18 rutine oral hygiene products.

Periodontal clinical parameters will be recorded, and saliva and supragingival dental plaque samples will be collected from all participants. The collected samples will be analysed for biomarkers associated with periodontal inflammation and oxidative stress. Interleukin-1 beta (IL-1β), C-reactive protein (CRP), and oxidative stress levels will be measured using biochemical analysis.

The findings of this study are expected to provide preliminary evidence regarding the biological effects of miswak on oral health and contribute to the current understanding of its potential role as an adjunctive oral hygiene tool.

研究设计

研究类型
Observational
观察模型
Cohort
时间视角
Prospective

入排标准

年龄范围
18 Years 至 60 Years(Adult)
性别
All
接受健康志愿者

入选标准

  • To be in the age range of 18-60 years
  • To have no systemic disease
  • To be diagnosed with gingivitis

排除标准

  • History of recent periodontal treatment

结局指标

主要结局

Change in Salivary Interleukin-1 Beta (IL-1β) Levels

时间窗: Pre-op 4 weeks and after 6 weeks

To evaluate the effect of adjunctive miswak use on salivary interleukin-1 beta (IL-1β) levels in patients with gingivitis. Salivary IL-1β concentrations will be measured using enzyme-linked immunosorbent assay (ELISA).

次要结局

  • Change in Clinical Periodontal Indices(Pre-op 4 weeks and after 6 weeks)
  • Change in Salivary C-Reactive Protein (CRP) Levels(Pre-op 4 weeks and after 6 weeks)
  • Change in Salivary Oxidative Stress Levels(Pre-op 4 weeks and after 6 weeks)

研究者

申办方类型
Other
责任方
Principal Investigator
主要研究者

Aysegul SARI

Assoc Prof

Mustafa Kemal University

研究点 (2)

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