Mucosal-Associated Invariant T Cells in Cases of Miscarriage
Completed
- Conditions
- Miscarriage
- Interventions
- Diagnostic Test: MAIT cells
- Registration Number
- NCT04492098
- Lead Sponsor
- Assiut University
- Brief Summary
Miscarriage is the most frequently encountered complication of pregnancy ranging from 10% to 30%. The etiology of recurrent spontaneous miscarriage (RSM) in 40%-50% of cases cannot be identified. Immunological disturbances have been suggested to play an important role.
Previous studies have focused that women with miscarriage have elevated NK cell numbers and activity both in the periphery and in the endometrium. Also, NK cells in women with RSM displayed an imbalance of Killer cell Ig-like receptors (KIRs) in favor of activating KIR leading to an unbalanced activation of dNK cytotoxicity and higher risk of miscarriage.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- Female
- Target Recruitment
- 50
Inclusion Criteria
- Regular marital life with the same partner.
- Regularly menstruating before current pregnancy.
- Spontaneous conception.
Exclusion Criteria
- Women with Polycystic ovarian syndrome or any endocrinal abnormalities like DM, thyroid disorders.
- History of abnormal uterine cavity proved by sonohysterography or hysteroscopy before pregnancy.
- Women with positive consanguinity.
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Arm && Interventions
Group Intervention Description study group MAIT cells women with spontaneous miscarriage
- Primary Outcome Measures
Name Time Method The percentages of MAIT cells and MAIT cells expressing CD56 and CD16 in comparison with NK cells and NKT cells in both blood and decidua 24 hours All markers will be measured by flow cytometry
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (1)
Ahmed Abbas
🇪🇬Assiut, Cairo, Egypt