Comparison of Conventional Free Breathing CT, 4D CT, and Integrated Active Breath Hold CT Image Acquisition for Lung Cancer
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 10
- 试验地点
- 1
- 主要终点
- Amount of inter- and intra-physician contouring variability on 4D CT, ABC CT, free breathing CT, and free breathing and ABC CBCT
研究概览
简要总结
This clinical trial studies computed tomography (CT) in diagnosing patients with lung cancer. Diagnostic procedures, such as CT, may help find and diagnose lung cancer.
详细描述
PRIMARY OBJECTIVES:
I. Conduct a prospective clinical imaging study to quantify the amount of inter- and intra-physician contouring variability on four dimensional (4D) CT, active breathing control (ABC) CT, free breathing CT, and free breathing and ABC cone beam (CB)CT.
II. Quantify the magnitude and distribution of target and organ at risk volume variations between the different imaging modalities.
III. Determine dosimetric changes related to contouring variations for tumor and normal tissue.
OUTLINE:
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Diagnostic
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Measurable disease on CT scan
- •Patients with lung cancer visible on CT who are scheduled to receive external beam radiation treatment will be eligible for this study
- •Patients must be able to perform ABC procedures
排除标准
- •Patients requiring continuous supplemental oxygen due to the requirement of spirometry during all imaging studies
- •No vulnerable populations will be enrolled (prisoners, children, pregnant females or institutionalized individuals)
- •Women of childbearing potential will undergo a pregnancy test
研究组 & 干预措施
Diagnostic (imaging studies)
Patients undergo conventional free breathing CT, 4D CT, ABC CT, ABC CBCT, and free breathing CBCT before undergoing radiation therapy.
干预措施: computed tomography (Procedure)
Diagnostic (imaging studies)
Patients undergo conventional free breathing CT, 4D CT, ABC CT, ABC CBCT, and free breathing CBCT before undergoing radiation therapy.
干预措施: 4-dimensional computed tomography (Procedure)
Diagnostic (imaging studies)
Patients undergo conventional free breathing CT, 4D CT, ABC CT, ABC CBCT, and free breathing CBCT before undergoing radiation therapy.
干预措施: cone-beam computed tomography (Procedure)
结局指标
主要结局
Amount of inter- and intra-physician contouring variability on 4D CT, ABC CT, free breathing CT, and free breathing and ABC CBCT
时间窗: up to 1 week
A two sided t-test with 5% level of significance will be used.
次要结局
- Magnitude and distribution of target and organ at risk volume variations between the different imaging modalities(up to 1 week)
- Dosimetric changes related to contouring variations for tumor and normal tissue(up to 1 week)