NCT01968525CompletedNot Applicable
The Effect of Chronic Anemia on Safety Period of Tracheal Intubation in Gynecology Patients
Conditions
Trial Snapshot
- Phase
- Not Applicable
- Status
- Completed
- Sponsor
- Fudan University
- Enrollment
- 45
- Locations
- 1
- Primary Endpoint
- duration of non-hypoxic apnoea
Study Overview
Brief Summary
- Every individual receiving a general anesthetic is at potential risk for developing a ''cannot intubate-cannot ventilate'' situation following anesthetic induction.
- Building up of oxygen reserves assumes great significance as this provides a longer duration of non-hypoxic apnea should one be faced with an unanticipated difficult airway.
- The main physiological functions of red blood cell hemoglobin are to deliver oxygen to the peripheral tissues.
- During anemia, a reduction in blood oxygen content occurs as a result of reduced Hb while arterial oxygenation and oxyhemoglobin saturation remain high.
- Previous studies about the duration of non-hypoxic apnoea focus on methods to improve the safety period of tracheal intubation.
- To our knowledge, there is no literature about the duration of non-hypoxic apnoea of anemia patients.
- The aim of this study was to assess the effect of chronic anemia on the duration of non-hypoxic apnoea during induction of anaesthesia.
Detailed Description
After breathing for 3 minutes, anesthesia induction was conducted. The endotracheal tube position was confirmed after anesthesia induction. Patients were left apneic with the endotracheal tube open to room air. The non-hypoxic apneic period was recorded as the time (in seconds) taken for the drop in pulse saturation to 90% or an apneic period of 10 min elapsed, whichever was earlier.
Study Design
- Study Type
- Interventional
- Allocation
- Randomized
- Intervention Model
- Parallel
- Primary Purpose
- Health Services Research
- Masking
- None
Eligibility Criteria
- Ages
- 18 Years to 45 Years (Adult)
- Sex
- Female
- Accepts Healthy Volunteers
- No
Inclusion Criteria
- •patients scheduled to undergo general anesthesia
- •American Society of Anesthesiologists Performance Status 1-2
Exclusion Criteria
- •Individuals with significant cardiorespiratory or cerebrovascular disease,
- •difficult intubation
- •history of epilepsy
- •body mass index >25 kg/m2,
- •and those who had smoking history in past 6 months
Outcomes
Primary Outcomes
duration of non-hypoxic apnoea
Time Frame: up to 6 months
Secondary Outcomes
No secondary outcomes reported
Investigators
Geng guiqi
PhD
Fudan University
Study Sites (1)
Loading locations...
Similar Trials
Completed
Not Applicable
Cerebral Perfusion During Induction of General AnesthesiaRadiographyInterventionalNCT03769142Assistance Publique - Hôpitaux de Paris100
Completed
Not Applicable
Arterial Stiffness and General Anesthesia Induced Hypotension in Patients on Angiotensin-converting Enzyme InhibitorsArterial StiffnessHypotensionNCT02416024University of Iowa72
Terminated
Not Applicable
Change in Brain Perfusion During Induction of General AnesthesiaInterventional RadiologyOrthopedic SurgeryNCT04288869Assistance Publique - Hôpitaux de Paris68
Completed
Not Applicable
Comparison of Hemodynamic Stability During Anesthesia Using Remimazolam and Sevoflurane in Minimally Invasive AVRAortic Valve StenosisRemimazolamNCT05864625Pusan National University Yangsan Hospital64
Completed
Not Applicable
Anesthesia-Related Peroperative Critical EventsNCT06426940Gamze Küçükosman1,904