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Clinical Trials/NCT01968525
NCT01968525CompletedNot Applicable

The Effect of Chronic Anemia on Safety Period of Tracheal Intubation in Gynecology Patients

Fudan University1 site in 1 country45 target enrollmentStarted: April 2013Last updated:
Conditions

Trial Snapshot

Phase
Not Applicable
Status
Completed
Enrollment
45
Locations
1
Primary Endpoint
duration of non-hypoxic apnoea

Study Overview

Brief Summary

  1. Every individual receiving a general anesthetic is at potential risk for developing a ''cannot intubate-cannot ventilate'' situation following anesthetic induction.
  2. Building up of oxygen reserves assumes great significance as this provides a longer duration of non-hypoxic apnea should one be faced with an unanticipated difficult airway.
  3. The main physiological functions of red blood cell hemoglobin are to deliver oxygen to the peripheral tissues.
  4. During anemia, a reduction in blood oxygen content occurs as a result of reduced Hb while arterial oxygenation and oxyhemoglobin saturation remain high.
  5. Previous studies about the duration of non-hypoxic apnoea focus on methods to improve the safety period of tracheal intubation.
  6. To our knowledge, there is no literature about the duration of non-hypoxic apnoea of anemia patients.
  7. The aim of this study was to assess the effect of chronic anemia on the duration of non-hypoxic apnoea during induction of anaesthesia.

Detailed Description

After breathing for 3 minutes, anesthesia induction was conducted. The endotracheal tube position was confirmed after anesthesia induction. Patients were left apneic with the endotracheal tube open to room air. The non-hypoxic apneic period was recorded as the time (in seconds) taken for the drop in pulse saturation to 90% or an apneic period of 10 min elapsed, whichever was earlier.

Study Design

Study Type
Interventional
Allocation
Randomized
Intervention Model
Parallel
Primary Purpose
Health Services Research
Masking
None

Eligibility Criteria

Ages
18 Years to 45 Years (Adult)
Sex
Female
Accepts Healthy Volunteers
No

Inclusion Criteria

  • patients scheduled to undergo general anesthesia
  • American Society of Anesthesiologists Performance Status 1-2

Exclusion Criteria

  • Individuals with significant cardiorespiratory or cerebrovascular disease,
  • difficult intubation
  • history of epilepsy
  • body mass index >25 kg/m2,
  • and those who had smoking history in past 6 months

Outcomes

Primary Outcomes

duration of non-hypoxic apnoea

Time Frame: up to 6 months

Secondary Outcomes

No secondary outcomes reported

Investigators

Sponsor Class
Other
Responsible Party
Principal Investigator
Principal Investigator

Geng guiqi

PhD

Fudan University

Study Sites (1)

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