Evaluation of Insecticide Treated Nets and Wall Liners for the Prevention of Malaria

Phase 3

Completed

• Conditions: Malaria
• Interventions: Other: Insecticide treated nets and wall liners; Other: Insecticide treated nets alone

• Registration Number: NCT01043796
• Lead Sponsor: Centers for Disease Control and Prevention

Brief Summary

The purpose of this study is to determine whether insecticide treated wall liners, in combination with insecticide treated nets, reduce the incidence of malaria infections compared to insecticide treated nets alone.

Detailed Description

Insecticide treated nets (ITNs) have been shown to reduce malaria related morbidity and mortality and are increasingly being scaled up throughout sub-Saharan Africa. However, ITNs alone are unlikely to reduce transmission to zero in most settings and additional vector control tools are necessary. One new promising strategy is the use of insecticide treated wall liners (ITWLs). These are textiles treated with an insecticide that are used to line the inner walls of houses. The wall liners are considered a long-lasting alternative to indoor residual spraying which is also used for malaria vector control but is expensive to implement.

Within 6 pairs of villages, we plan to randomly allocate one village in each pair to receive either ITNs or ITNs plus ITWLs. Households will be randomly selected from each village and all children between the ages of 6 months and 11 years will be enrolled in a cohort study. The children will be cleared of existing infections and then followed monthly until they are found to be infected with malaria. The study will last for 6 months and will demonstrate whether the ITWLs provide additional protection against malaria over that provided by the use of ITNs.

Study Timeline

• Study First Submitted: 2010-01-06
• Study First Submitted QC: 2010-01-06
• Study First Posted: 2010-01-07
• Study Start: 2010-05
• Primary Completion: 2011-06
• Study Completion: 2014-12
• Status Verified: 2015-02
• Last Update Submitted: 2015-02-02
• Last Update Posted: 2015-02-03

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 1730

Inclusion Criteria

• Age 6 months up to 11 years
• Living in the study area and remaining in the study area for the duration of the study
• Informed consent provided by parents

Exclusion Criteria

• No informed consent
• Living outside the study area, or likely to move outside study area
• Severely ill and unlikely to be able to complete study

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
Insecticide treated nets and wall liners	Insecticide treated nets and wall liners	-
Insecticide treated nets alone	Insecticide treated nets alone	-

Primary Outcome Measures

Name	Time	Method
Incidence of new malaria infections	Monthly

Trial Locations

Locations (1)

Kenya Medical Research Institute; 🇰🇪 Kisumu, Nyanza, Kenya