Safety and Efficacy of Deep Transcranial Magnetic Stimulation (dTMS) in childhood and adolescent onset obsessive compulsive disorder
Phase 2
- Conditions
- Health Condition 1: F422- Mixed obsessional thoughts and acts
- Registration Number
- CTRI/2023/07/055682
- Lead Sponsor
- CIP
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- ot Yet Recruiting
- Sex
- Not specified
- Target Recruitment
- 0
Inclusion Criteria
1.Diagnosis of Obsessive-Compulsive Disorder using Diagnostic Criteria for Research (DCR) of ICD 10 DCR (World Health Organization, 1993)
2.Age group of 10-20 years with either sex
3.Childrenâ??s Yale Brown obsessive-compulsive scale (CY-BOS) score of 15 or above
4.Patients (>=18years) or Parents giving written informed consent ( <18 years)
Exclusion Criteria
1.Co-morbid severe depression as measured by a HAM-D score of 23 or more
2.Patients with co-morbid neurological or any other psychiatric disorder
3.Patients who cannot undergo MRI scan
4.Colour blind, as indicated by Ishiharaâ??s charts
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Safety & efficacy of deep TMS in children & adolescent population as assessed by TMSens_Q & reduction in score of Childrenâ??s Yale-Brown Obsessive-Compulsive Scale (CY-BOCS).Timepoint: Safety & efficacy of deep TMS in children & adolescent population as assessed by TMSens_Q & reduction in score of Childrenâ??s Yale-Brown Obsessive-Compulsive Scale (CY-BOCS) after 2 weeks of dTMS treatment .
- Secondary Outcome Measures
Name Time Method fMRI task-based assessment of difference in functional connectivity between mPFC & ACC at baseline and after application of deep TMS and reduction in scores of severity of clinical global inventory.Timepoint: Secondary outcome variables are fMRI task-based assessment of difference in functional connectivity between mPFC & ACC at baseline and after application of deep TMS and reduction in scores of severity of clinical global inventory after 2 weeks of dTMS treatment.