Based on gut microbiota-gut-brain axis to explore the clinical of electroacupuncture in the treatment of post-stroke cognitive impairment
- Conditions
- stroke
- Registration Number
- ITMCTR2200005975
- Lead Sponsor
- The First Affiliated Hospital of Henan University of Chinese Medicine
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Pending
- Sex
- All
- Target Recruitment
- Not specified
?China guidelines for the diagnosis and treatment of acute ischemic stroke 2018 and China guidelines for the prevention and treatment of cerebrovascular diseases;?were confirmed to have a history of ischemic stroke by CT or MRI;?were determined the degree of cognitive impairment after assessing by mini-mental state examination (MMSE) and Montreal Cognitive Assessment (MoCA) which occurred after ischemic stroke;?are already ill more than or equal to one month and less than or equal to one year; ?never use drugs improving cognitive function were used before enrollment;?are conscious and have stable vital signs.
?Participants suffered from other diseases that could lead to cognitive impairment, such as intracranial space occupying lesions, brain trauma, aneurysms, etc;?Patients with other diseases will lead to the failure of cognitive impairment examination, such as abnormal audio-visual function, mental disorder and so on;?The patient had cognitive impairment or had been diagnosed with dementia before this onset;?The patient has other serious diseases, such as immune diseases, endocrine diseases and abnormal liver and kidney function;?Women is pregnant or breastfeeding;?The patient has coagulation dysfunction.
Study & Design
- Study Type
- Interventional study
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method ADL score (Barthel Index);Intestinal flora analysis;Detection of related indexes and factors of blood-brain barrier permeability;MMSE score;Inflammatory cytokines;MOCA score;
- Secondary Outcome Measures
Name Time Method