Comparitive study between effect of IV Lignocaine 60mg versus 30mg as pretreatment for prevention of pain during Propofol induction
试验速览
- 阶段
- 不适用
- 状态
- 尚未招募
- 发起方
- 入组人数
- 50
- 试验地点
- 1
- 主要终点
- IV Lignocaine 60mg will be better than IV Lignocaine 30mg as pretreatment in preventing Propofol injection pain.
研究概览
简要总结
Propofol is a rapidly acting and most commonly used intravenous inducing
agent for general anaesthesia due to its smooth induction and rapid recovery
properties.The side effects of Propofol include hypotension,apnea,pain on
injection and myoclonus.Pain on injection is a major problem with incidence
of 28%-85%.Several methods have been administered over the years to
reduce the pain associated with IV injection of Propofol.These include non
drug category, drug category and conjugation of two.The non drug category
includes injection sites,needle sizes,temperature, venous occlusion, micro
filtration.The drug category constituted various drugs or drug combination.
• Lignocaine pretreatment is most commonly used to decrease Propofol
injection pain. Intravenous Lignocaine hydrochloride a cation solution
when exposed to lipids in Propofol , liberates protons and decreases
the pH of the solution,the lower pH decreases the anions in
Propofol,hence more amount of Propofol enters into the lipid phase
and will cause reduced pain on injection.
• The study is aimed at comparing effect of two different doses of IV
Lignocaine pretreatment for prevention of pain during Propofol
induction and to find the effect of lower dose of Lignocaine with
60seconds venous occlusion.
研究设计
- 研究类型
- Interventional
- 分配方式
- Coin toss, Lottery, toss of dice, shuffling cards etc
- 盲法
- Participant and Investigator Blinded
入排标准
- 年龄范围
- 18.00 Year(s) 至 60.00 Year(s)（—）
- 性别
- All
入选标准
- •1]Patients willing for the study- informed consent 2]ASA 1 and 2.
排除标准
- •1]ASA 3 and 4 patients 2]Patients with hypersensitivity or allergies to study drug.
- •3]Uncontrolled Diabetes and Hypertension, Cardiovascular diseases,liver and kidney disorders, psychiatric disorders.
结局指标
主要结局
IV Lignocaine 60mg will be better than IV Lignocaine 30mg as pretreatment in preventing Propofol injection pain.
时间窗: Haemodynamic parameters will be recorded at 15seconds and 1min after Propofol injection, Pain assessment will be done 5,10 and 15 seconds after Propofol injection
次要结局
未报告次要终点
研究者
DrSeema Dharmatti
Sapthagiri Institute of Medical Sciences and Research Centre