The Influencing Factors of Vancomycin Trough Level and the Rate Achieving the Target Trough Level

Completed

• Conditions: Vancomycin

• Registration Number: NCT03806543
• Lead Sponsor: Southeast University, China

Brief Summary

The aim of this study was to assess factors that may influence vancomycin trough level and the rate achieving the target trough level in critically ill patients.

Detailed Description

This retrospective observational study included adult patients treated with intravenous vancomycin in intensive care unit of Zhongda Hospital from January 2015 to December 2017. Vancomycin dose was based on international consensus and adjusted according to estimated glomerular filtration rate (eGFR) calculated by the Cockcroft-Gault equation. vancomycin trough level (VTL) was retained at steady state (after the third dose). Linear regression was performed to determine the correlation between factors prior to the first vancomycin dose and VTL. Distribution of VTL and percentage of patients achieving the target trough level (15-20mg/L) was observed in different renal function.

Study Timeline

• Study Start: 2015-01-01
• Primary Completion: 2017-12-31
• Study Completion: 2017-12-31
• Study First Submitted: 2018-12-22
• Status Verified: 2019-01
• Study First Submitted QC: 2019-01-15
• Last Update Submitted: 2019-01-15
• Study First Posted: 2019-01-16
• Last Update Posted: 2019-01-16

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 165

Inclusion Criteria

• Adult ICU patients (age≥18 years) treated with intravenous vancomycin were included

Exclusion Criteria

• Chronic renal dysfunction and acute renal injury patients treated with Renal Replacement therapy
• VTL was not retained at steady-state
• Vancomycin treatment time≤48h
• Vancomycin dose did not meet study definitions
• Palliative care

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Rate of patients achieving the target vancomycin trough（15-20mg/L）	3 years	Vancomycin trough level was retained at steady state (after the third dose). If a patient has multiple measurements of vancomycin trough level, the first measurement is collected.Rate of patients achieving the target trough level (15-20mg/L) was observed.