Angiotensin II Pathway and Postoperative Hypoxemia

Completed

• Conditions: Aortic Dissection
• Interventions: Other: No intervention

• Registration Number: NCT05055570
• Lead Sponsor: Beijing Anzhen Hospital

Brief Summary

Acute type A aortic dissection is often accompanied by postoperative hypoxemia, the cause of which is not fully understood. Angiotensin II is an important component of the renin-angiotensin system (RAS), which has been suggested to be involved in the development of aortic dissection and pulmonary inflammation.The purpose of this study was to investigate the role and mechanism of angiotensin II pathway in postoperative hypoxemia after acute type A aortic dissection, and to provide reference for clinical application

Detailed Description

Not available

Study Timeline

• Study Start: 2021-08-12
• Study First Submitted: 2021-09-07
• Study First Submitted QC: 2021-09-22
• Study First Posted: 2021-09-24
• Primary Completion: 2022-06-01
• Study Completion: 2022-06-01
• Status Verified: 2023-04
• Results First Submitted: 2023-04-24
• Results First Submitted QC: 2023-04-24
• Last Update Submitted: 2023-04-24
• Results First Posted: 2024-01-26
• Last Update Posted: 2024-01-26

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 88

Inclusion Criteria

• patients undergoing surgery for acute type A aortic dissection
• age between 18 to 80

Exclusion Criteria

• perioperative severe cardiac insufficiency
• rejection of consent

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
Hypoxemia group	No intervention	oxygenation index (OI)≤200
Non-hypoxemia group	No intervention	oxygenation index (OI)\>200

Primary Outcome Measures

Name	Time	Method
The Difference Concentrations of ANG II in Serum Between Patients With and Without Postoperative Hypoxemia.	Within 24 hours after surgery	Blood samples were taken within 24 hours after operation to detect the contents of ANG II in serum. Postoperative hypoxemia is defined by the oxygenation index (OI), which is the ratio of arterial partial pressure of oxygen to fraction inspired oxygen (PaO2 / FiO2), of less than or equal to 200 for two consecutive times within the first 24 h after operation

Secondary Outcome Measures

Name	Time	Method
Duration of Stay in the Intensive Care Unit	up to 60 days	Duration of Stay in the intensive care unit after surgery
The Risk Factors for Postoperative Hypoxemia in Stanford Type A Acute Aortic Dissection Patients.	up to 60 days	Basic characteristics, intraoperative details, biochemical parameters and outcome results were obtained, and blood was collected within 24 hours after surgery for the measurement of ANG II, sACE2 and mir-145 concentrations. Univariate analysis was first performed to identify the potential risk factors for postoperative hypoxemia. Multivariate logistic regression analysis was performed for factors with P \< 0.05 or that were considered clinically important.

Trial Locations

Locations (1)

Anzhen hospital, Beijing; 🇨🇳 Beijing, Beijing, China