Telomeres Evaluation in Endometriosis

• Conditions: Endometriosis
• Interventions: Procedure: tissue biopsy during surgical treatment

• Registration Number: NCT01809561
• Lead Sponsor: Meir Medical Center

Brief Summary

The purpose of the study is to assess the telomere array of different endometriosis tissue and endometrium from women with endometriosis compared to healthy women.

Our hypothesis is that telomere shortening and high telomerase activity will be found in tissues from women with endometriosis.

Detailed Description

The purpose of the study is to assess the telomere array of different endometriosis tissue and endometrium from women with endometriosis compared to healthy women. Our hypothesis is that telomere shortening and high telomerase activity will be found in tissues from women with endometriosis, compared to women without endometriosis.

A prospective study that compares telomeres and telomerase levels in different lesions of endometriosis and endometrial tissue of women with endometriosis and healthy women without endometriosis. The study group will consist of women with suspected endometriosis facing surgical treatment and the control group will consist of healthy women facing gynecologic surgery for different indication.

We will sample endometrial tissue in both groups. In the study group we additionally will sample endometriosis lesion.

The samples collected will test for histological diagnosis of endometriosis and verification tests will be done to characterize the telomeres array and telomerase levels and other characteristics for genomic instability such as spontaneous aneuploidy.

expect telomere shortening and high telomerase activity in endometrial tissue and in endometriosis tissue sample, that won't characterize samples from women without endometriosis.

Study Timeline

• Status Verified: 2013-02
• Study First Submitted: 2013-03-10
• Study First Submitted QC: 2013-03-10
• Study First Posted: 2013-03-12
• Last Update Submitted: 2013-04-07
• Last Update Posted: 2013-04-09
• Study Start: 2013-05
• Primary Completion: 2015-02
• Study Completion: 2015-02

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: Female
• Target Recruitment: 30

Inclusion Criteria

• women with suspected endometriosis facing surgical treatment

Exclusion Criteria

• no endometriosis on histology
• malignant finding on histology

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
endometriosis	tissue biopsy during surgical treatment	The study group will consist of women with suspected endometriosis facing surgical treatment
no endometriosis	tissue biopsy during surgical treatment	The control group will consist of healthy women facing gynecologic surgery for different indication

Primary Outcome Measures

Name	Time	Method
characterize the telomeres array and telomerase levels and other characteristics for genomic instability such as spontaneous aneuploidy in endometriosis tissue.	the tissue sample will colect at time of surgery

Trial Locations

Locations (1)

OBGYN department, Meir Medical Center; 🇮🇱 Kfar-Saba, Israel