Calcium-phosphate Complications Induced by IV Iron Supplementation in Patients With Rendu-Osler Disease

Recruiting

• Conditions: Rendu Osler Disease

• Registration Number: NCT05544669
• Lead Sponsor: University Hospital, Strasbourg, France

Brief Summary

Hypophosphatemia induced by treatments with injectable iron is a frequent side effect already reported during marketing. Situations of osteomalacia secondary to these hypophosphatemias are rarer and reported in the form of case reports in the literature. Hypophosphatemia in this context is attributed to an excess of FGF-23 (defect of degradation linked to carbohydrates in martial preparations) with renal leakage of phosphate.

Rendu-Osler disease (ROM) is an autosomal dominant genetic disease, favoring the formation of vascular malformations, including nasal and digestive telangiectasias causing repeated bleeding, even hemorrhages. Iron deficiency is frequent and profound there, and oral martial treatments are often insufficient to compensate for these losses. Regular iron infusions, to avoid transfusions, are often necessary.

Detailed Description

Not available

Study Timeline

• Study Start: 2022-08-01
• Study First Submitted: 2022-09-13
• Study First Submitted QC: 2022-09-13
• Study First Posted: 2022-09-16
• Status Verified: 2023-12
• Last Update Submitted: 2023-12-12
• Last Update Posted: 2023-12-19
• Primary Completion: 2024-07-21
• Study Completion: 2024-07-21

Recruitment & Eligibility

• Status: RECRUITING
• Sex: All
• Target Recruitment: 220

Inclusion Criteria

Not provided

Exclusion Criteria

Not provided

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Occurrence of a bone crack and/or fracture	Files analysed retrospectively from January 01, 2018 to December 31, 2022 will be examined

Trial Locations

Locations (1)

Service de Médecine interne - CHU de Strasbourg - France; 🇫🇷 Strasbourg, France