Randomized Controlled Trial of Gradual Versus Sudden Weaning From Nasal CPAP in Preterm Neonates
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 56
- 试验地点
- 1
- 主要终点
- Weight when preterm neonates could come off nasal CPAP
研究概览
简要总结
To compare the 2 methods of weaning of nasal CPAP in premature babies born at 32 weeks or less
详细描述
Objective
To study the weight and the post menstrual age (PMA) at the time of nasal CPAP (NCPAP) wean utilizing the method of sudden wean as compared to gradual wean. . Methods: A prospective randomized trial was conducted comparing sudden weaning with gradual weaning from NCPAP in neonates with gestational age (GA) <32 weeks. The patients were randomized to one of the two methods of weaning from NCPAP and their success was compared.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 年龄范围
- 24 Weeks 至 32 Weeks（Child）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •All babies born with GA <32 weeks admitted to the neonatal intensive care units at the Maimonides Infant and Children's Hospital, between 1st January 2008 and 31st March 2009 and required to be on NCPAP for longer than 48 hours.-
排除标准
- •Those with severe congenital anomalies and chromosomal defects including congenital heart disease and neurological malformations, chest wall or airway abnormalities and lung hypoplasia, were excluded from the cohort
研究组 & 干预措施
Sudden wean from Nasal CPAP
Usual practice to wean the preterm neonates from nasal CPAP
Gradual wean from Nasal CPAP
Nasal CPAP for gradual wean group it was cycled off for 3 hours alternating with 3 hours on for first 48 hours, if successful the cycle was extended to 6 hours off and 3 hours on for the next 48 hours. If the baby tolerated this regime the prongs were removed and CPAP was kept off.
干预措施: Gradual weaning from Nasal CPAP in preterm neonates (Procedure)
结局指标
主要结局
Weight when preterm neonates could come off nasal CPAP
时间窗: During the initial NICU stay
Weight when preterm neonates could come off nasal CPAP
Post-menstrual age when preterm neonates could come off nasal CPAP
时间窗: During the initial NICU stay
Post-menstrual age when preterm neonates could come off nasal CPAP
次要结局
- Weights when the neonates could come off oxygen(During the initial NICU stay)
- length of stay in the hospital(During the initial NICU stay)
- Post-menstrual age when preterm neonates could come off oxygen(During the initial NICU stay)
研究者
Shantanu Rastogi
Neonatologist
Maimonides Medical Center