Transdermal Fentanyl Patch for Postoperative Analgesia in Total Knee Arthroplasty
Overview
- Phase
- Phase 4
- Intervention
- transdermal fentanyl patch
- Conditions
- Postoperative Pain
- Sponsor
- Khon Kaen University
- Enrollment
- 40
- Locations
- 1
- Primary Endpoint
- intravenous morphine consumption
- Status
- Completed
- Last Updated
- 15 years ago
Overview
Brief Summary
The purpose of this study is to determine whether transdermal fentanyl patch
Detailed Description
Total knee arthroplasty (TKA) has severe postoperative pain that prevents mobilization of patient. The best standard analgesia regimen is patient-control analgesia (PCA) which requires a PCA pump that is expensive. Transdermal fentanyl patch (TFP)(50 mcg/hr) can release fentanyl into blood circulation at rate 50 mcg/hr for three days. It has slow onset of about 12-14 hours, so it's used to treat chronic pain, not popular for a cure of pain. If the investigators apply TFP at appropriate times, i.e. 12-14 hours before surgery, it may be used to treat acute postoperative pain. If it can give good analgesia for TKA, it can replace PCA. The benefit is that it is much cheaper and more convenient.
Investigators
Eligibility Criteria
Inclusion Criteria
- •Patients who were scheduled for TKA gave informed consent for inclusion
Exclusion Criteria
- •ASA class 3-4
- •Known allergy to any of the drugs to be used, eg. TFPs ,MO
- •History of substance or alcohol abuse, and tolerance or dependence on opioids
- •Can not use PCA
- •Contraindication for spinal anesthesia
Arms & Interventions
group 1
group 1 = transdermal fentanyl patch
Intervention: transdermal fentanyl patch
group 2
placebo patch
Intervention: placebo patch
Outcomes
Primary Outcomes
intravenous morphine consumption
Time Frame: 48 hours
Secondary Outcomes
- Pain score(48 hours)