Transdermal Fentanyl Patch for Postoperative Analgesia After Abdominal Surgery: a Randomized Placebo-controlled Trial
Overview
- Phase
- Not Applicable
- Intervention
- transdermal fentanyl patch (50 mcg/hour)
- Conditions
- Postoperative Pain Relief
- Sponsor
- Khon Kaen University
- Enrollment
- 50
- Locations
- 1
- Primary Endpoint
- morphine consumption
- Status
- Completed
- Last Updated
- 13 years ago
Overview
Brief Summary
Abdominal surgery causes severe postoperative pain. Multi-modal pain therapy is usually applied but there is no perfect choice. It depends on physician's skill and situation. The best regimen is patient-controlled analgesia, but it requires an expensive equipment. Transdermal fentanyl patch, usually used in chronic pain relief, can steadily release fentanyl into blood stream for 72 hours, but it has slow onset of 12 hours.
Hypothesis: If Transdermal fentanyl patch is applied 10-12 hours before surgery, it may provide good analgesia for 72 hours.
Investigators
Thepakorn Sathitkarnmanee
Associate Professor
Khon Kaen University
Eligibility Criteria
Inclusion Criteria
- •age =\>18 years
- •scheduled for abdominal surgery
Exclusion Criteria
- •ASA class \> 3
- •Known allergy to fentanyl or morphine
- •History of substance or alcohol abuse, and tolerance or dependence on opioids
- •Combined epidural block
- •Can't use PCA, abnormal renal / liver function
Arms & Interventions
Transdermal fentanyl patch
Transdermal fentanyl patch, 50 mcg/hour, was attached to the patient's chest wall at 10 pm the day before surgery
Intervention: transdermal fentanyl patch (50 mcg/hour)
Placebo
Placebo patch was attached to the patient's chest wall at 10 pm the day before surgery
Intervention: Placebo
Outcomes
Primary Outcomes
morphine consumption
Time Frame: 24 hours
Compare the cumulative morphine consumption during 24 hours postoperative of both study and control groups.
Secondary Outcomes
- morphine consumption(48 and 72 hours)