The Optimal Timing of Carbon Dioxide Insufflation During Colonoscopy in Unsedated Patients

Not Applicable

Completed

• Conditions: Outpatients
• Interventions: Procedure: Insufflation with CO2

• Registration Number: NCT01415076
• Lead Sponsor: Tri-Service General Hospital

Brief Summary

Insufflation of carbon dioxide (CO2) instead of air can reduce pain resulting from colon distension after colonoscopy because CO2 is rapidly absorbed from the colon and excreted through the lungs. This reduces the effects of colonic distension and minimizes intracolonic gas at the end of the examination. The aims of the study were to evaluate the timing of administering CO2 insufflation and to identify predictors of discomfort for colonoscopy.

Detailed Description

Not available

Study Timeline

• Study Start: 2010-09
• Primary Completion: 2011-06
• Study Completion: 2011-06
• Study First Submitted: 2011-08-10
• Study First Submitted QC: 2011-08-10
• Study First Posted: 2011-08-11
• Status Verified: 2012-09
• Last Update Submitted: 2012-09-03
• Last Update Posted: 2012-09-05

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 200

Inclusion Criteria

• patients with an appropriate indication for colonoscopy were considered eligible.

Exclusion Criteria

• Exclusion criteria included severe hematochezia, acute colonic pseudo-obstruction, known obstructive lesions, age <18 years, prior colon resection, fulminant colitis, chronic obstructive pulmonary disease requiring oxygen, and a medical history of CO2 retention. Patients that required only a partial colonoscopy or were unable to read or understand Chinese were also excluded.

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
Insertion without CO2 insufflation	Insufflation with CO2	Patients were randomly allocated to receive whole procedure or extubation-only CO2 insufflation, using a randomized computer-generated list.
Insertion with CO2	Insufflation with CO2	Patients were randomly allocated to receive whole procedure or extubation-only CO2 insufflation, using a randomized computer-generated list.

Primary Outcome Measures

Name	Time	Method
abdominal pain during and after colonoscopy	One day	Pain was recorded on a ten-point visual analog scale (0- no pain, 10- worst imaginable pain) at left-sided colonoscopic insertion, right-sided colonoscopic insertion, and at 1, 3, 6, and 24 hours postprocedure.

Secondary Outcome Measures

Name	Time	Method
delayed bleeding	One day
colonoscopic cecal intubation time	One day
completeness of intubation	One day
loop formation	One day

Trial Locations

Locations (1)

Division of Gastroenterology, Tri-Service General Hospital; 🇨🇳 Taipei, Taiwan