Cardiovascular Risk Markers in Spinal Cord Injured Subjects of the Wheelchair Dancer Study

Completed

• Conditions: Cardiovascular Risk Factor; SCI - Spinal Cord Injury

• Registration Number: NCT03352505
• Lead Sponsor: Paracelsus Medical University

Brief Summary

The present study will analyze if exercise is able to elicit the well-known anti-atherogenic effects in patients with SCI. This will be evaluated by measuring vascular parameters such as endothelial and inflammatory blood markers, echocardiography of the heart and peripheral vessels, as well as blood pressure and arterial stiffness, in subjects performing either wheelchair dancing, wheelchair marathon or no sports. Further, it will be investigated, whether there is an association between neuroplasticity and cardiovascular health, as measured by electroencephalography (EEG), transcranial magnetic stimulation (TMS) and blood levels of the brain-derived neurotrophic factor (BDNF).

We hypothesize that the cardiovascular, physical and psychological benefits of wheelchair dancing and/or wheelchair marathon parallel improved neuroplasticity in SCI-patients

Detailed Description

Not available

Study Timeline

• Study Start: 2017-10-01
• Study First Submitted: 2017-11-16
• Study First Submitted QC: 2017-11-20
• Study First Posted: 2017-11-24
• Primary Completion: 2019-10-01
• Status Verified: 2021-01
• Study Completion: 2021-01-28
• Last Update Submitted: 2021-01-28
• Last Update Posted: 2021-01-29

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 54

Inclusion Criteria

wheelchair users independent of the cause of the walking impairment, preferably with spinal cord injury.

Exclusion Criteria

metallic implanters, additional neurologic pathologies, pregnancy

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Evaluation of echocardiography results between different study groups	October 2017- June 2018	Evaluation of echocardiography comparing healthy individuals and patients using wheelchairs (three different groups).
comparison of cardiovascular risk factors between different study groups	October 2017- June 2018	measurement for arterial stiffness parameters, via pulse wave analysis. Comparison between healthy individuals and patients using wheelchairs (three different groups).

Trial Locations

Locations (2)

Department of Sports Medicine, Prevention and Rehabilitation Paracelsus Medical University; 🇦🇹 Salzburg, Austria

Department of Neurology, Christian Doppler Klinik, Paracelsus Medical University Salzburg; 🇦🇹 Salzburg, Austria