Prevalence of Acute Critical Neurological Disease in Children: a Global Epidemiological Assessment

Completed

• Conditions: Brain Mass; Stroke; Spinal Cord Disease; Hydrocephalus; Cardiac Arrest; Traumatic Brain Injury; Status Epilepticus

• Registration Number: NCT02381977
• Lead Sponsor: University of Pittsburgh

Brief Summary

PANGEA is an international prospective point prevalence study to describe the epidemiology, interventions, and outcomes in children with acute critical brain disease.

Detailed Description

Not available

Study Timeline

• Study Start: 2011-11
• Primary Completion: 2012-10
• Study Completion: 2014-09
• Study First Submitted: 2015-02-16
• Status Verified: 2015-03
• Study First Submitted QC: 2015-03-02
• Last Update Submitted: 2015-03-02
• Study First Posted: 2015-03-06
• Last Update Posted: 2015-03-06

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 922

Inclusion Criteria

1. Children aged 7 days to 17 years inclusively and admitted to an ICU (ICU can be classified as general, cardiac, trauma, etc).
2. Children with acute or acute on chronic neurologic disease that occurred just prior to hospital admission or occurred during the hospital admission.
3. Acute neurologic disease is secondary to TBI, stroke, brain mass, hydrocephalus, cardiac arrest, status epilepticus, CNS infection/inflammation, or spinal cord injury.

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Exclusion Criteria

1. Children with acute perinatal neurologic disease.
2. Children with isolated chronic brain injury and no acute neurologic disease.

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Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Prevalence of acute brain insult	4 days over a 1 year period

Secondary Outcome Measures

Name	Time	Method
Mortality	Hospital discharge or 3 months