Trends of Morbidity and Mortality Among Thai HIV-infected and HIV-uninfected Patients: a Five-year Prospective Cohort Study

Completed

• Conditions: HIV Infection; Healthy

• Registration Number: NCT01634477
• Lead Sponsor: Thai Red Cross AIDS Research Centre

Brief Summary

1. To describe the morbidity and clinical characteristics among HIV-infected patients and HIV-uninfected patients.

2. To identify the risk factors for the complication or morbidity among HIV-infected patients and HIV-uninfected patients.

3. To describe the mortality among HIV-infected patients and HIV-uninfected patients.

4. To identify the risk factors for the cause of death among HIV-infected and HIV-uninfected patients.

Detailed Description

The information obtained from this study would be very important in planning future holistic care of HIV-infected patients in our institutes as well as in national policy. Results from the study could be used to develop proper long-term management guidelines for people living with HIV (PLHIV) in Thailand targeted at preventable conditions such as metabolic diseases and certain cancers.

Study Timeline

• Study Start: 2010-01
• Study First Submitted: 2012-07-02
• Study First Submitted QC: 2012-07-05
• Study First Posted: 2012-07-06
• Primary Completion: 2020-10
• Status Verified: 2021-07
• Study Completion: 2021-07
• Last Update Submitted: 2024-11-22
• Last Update Posted: 2024-11-25

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 816

Inclusion Criteria

HIV-infected patients group

• HIV positive
• 30 years of age or older, both male and female
• Thai nationality
• Written research informed consent

HIV-uninfected patients group

• HIV un-infected
• 30 years of age or older, both male and female
• Thai nationality
• Written research informed consent

Exclusion Criteria

HIV-infected patients group

• Systolic BP ≥ 130 or Diastolic BP ≥ 85mm Hg or on the treatment
• Fasting blood sugar > 126 mg/dl or on the treatment
• Proteinuria
• Creatinine > 1.5 mg/dl
• Recent hospitalization
• Patient who are having mental disease HIV-uninfected patients group
• Systolic BP ≥ 130 or Diastolic BP ≥ 85mm Hg or on the treatment
• Fasting blood sugar > 126 mg/dl or on the treatment
• Proteinuria
• Creatinine > 1.5 mg/dl
• Recent hospitalization
• Patient who are having mental disease

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
morbidity	60 months	development of other diseases
HIV related illness	60 months	development of opportunistic infection such as Non-Hodkin's lymphoma, Kaposi's sarcoma
Non HIV-related illness	60 months	development of Dyslipidemia, Hypertension, DM, CVD , Cancer, osteopenia, osteoporosis, Renal disease, liver disease
CVD	60 months	development of CVD
mortality	60 months	death

Trial Locations

Locations (1)

The Thai Red Cross AIDS Research Centre; 🇹🇭 Pathum Wan, Bangkok, Thailand