Influence of Captopril use on Blood Pressure Response Measured After a Single Bout of Strength Exercise in Men with High Blood Pressure
Phase 4
Recruiting
- Conditions
- Hypertension.C14.907.489
- Registration Number
- RBR-8mx5g6
- Lead Sponsor
- Escola de Educação Física e Esporte da Universidade de São Paulo
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Recruiting
- Sex
- Male
- Target Recruitment
- Not specified
Inclusion Criteria
Men. Aged between 30 and 60 years. Non smokers. Physically inactives (did not perform physical activity more than twice a week). Normotensives and hypertensives will form different groups. Hypertensives should not have end organ damage or secondary causes of hypertension according to the diagnotic rotine of the Hypertension League of Clinical Hospital, Faculty of Medicine, USP.
Exclusion Criteria
Subjects with obesity (body mass index equal or greater than 30 kg/m2). Subjects with diabetes (fasting glycemia equal or greater than 126 mg/dl). Subjects with cardiac diseases (previous diagnosis or alteration on resting or exercise ECG). Subjects who do not tolerate the study medication.
Study & Design
- Study Type
- Intervention
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method post-exercise hypotension - evaluated by the measurement of clinic (auscultatory) and ambulatorial (oscillometric) blood pressure before and after rest and resistance exercise while receiving placebo and captopril.
- Secondary Outcome Measures
Name Time Method hemodynamics - evaluated by the measurement of cardiac output (CO2 rebreathing)and heart hate (ECG) performed before and after rest and resistance exercise while receiving placebo and captopril. Systemic vascular resistance and stroke volume will be calculated.;Autonomic modulation - evaluated by the measurement of heart rate and blood pressure variabilities (spectral analysis) performed before and after rest and resistance exercise while receiving placebo and captopril;Vascular function - evaluated by the measurement of baseline blood flow and its response to the reactive hyperemia maneuver (venous occlusion pletismography) performed before and after rest and resistance exercise while receiving placebo and captopril.