The effect of prophylactic antibiotics in colorectal endoscopic submucosal dissectio

Not Applicable

Conditions: Neoplasms

Registration Number: KCT0001102

Lead Sponsor: Konkuk University Medical Center

Brief Summary: Background and Aims: Endoscopic submucosal dissection (ESD) is currently commonly performed, but colorectal ESD has a substantial risk of complications, including post-ESD electrocoagulation syndrome (PEECS). We investigated whether the use of prophylactic antibiotics can reduce the occurrence of PEECS. Methods: Patients who underwent colorectal ESD were randomly assigned to one of two treatment regimens. Ampicillin/sulbactam mixed with normal saline was administered 1 h prior to ESD in group I, and then additionally injected every 8 h twice more. In group II, normal saline, without antibiotics, was administered following the same schedule. We investigated the characteristics of the patients and tumors, the incidence of PEECS, laboratory findings, and the visual analog scale (VAS) score for abdominal pain measured on the morning after ESD. Results: A total of 100 cases (50 per group) were finally analyzed and 97 tumors were successfully resected en bloc. The number of patients having C-reactive protein (CRP) levels = 1 mg/dL and the number of the patients having VAS scores for abdominal pain = 1 were greater in group II than in group I (p = 0.008 and 0.023, respectively). The incidence of PEECS in group II was also higher than that in group I (1 and 8 in the group I and II, respectively, p = 0.031). Conclusions: The prophylactic use of ampicillin/sulbactam in colorectal ESD is associated with the reduced risk of PEECS, decreased CRP levels, and decreased abdominal pain. The use of prophylactic antibiotics in colorectal ESD may be an effective tool for reducing the risk of PEECS.

Detailed Description: Not available

Recruitment & Eligibility

Status: ot yet recruiting

Sex: All

Target Recruitment: 80

Inclusion Criteria

1. 20-90 years old
2. patients who underwent ESD due to colorectal tumor in the Konkuk University Hospital were included.
3. Patients who signed the consent.

Exclusion Criteria

The exclusion criteria were: age less than 20 years or more than 90 years; pregnancy; past history of a penicillin allergy; patients who refused to sign the consent.