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Clinical Trials/NCT05560880
NCT05560880
Recruiting
Not Applicable

The Effects of High Intensity Interval Gait Training vs. Moderate Intensity Continuous Gait Training in Multiple Sclerosis

Hunter College of City University of New York1 site in 1 country30 target enrollmentSeptember 1, 2022

Overview

Phase
Not Applicable
Intervention
Not specified
Conditions
Multiple Sclerosis
Sponsor
Hunter College of City University of New York
Enrollment
30
Locations
1
Primary Endpoint
Change in Six minute walk test time from before to after the intervention
Status
Recruiting
Last Updated
3 years ago

Overview

Brief Summary

Over 90% of persons with MS (pwMS) complain of difficulty with walking. High intensity interval gait training (HIIGT), where persons alternate brief periods of walking at high speeds with periods of rest has been found to improve walking in other neurologic diagnoses. However its impact on pwMS is not known. Most gait training in MS is done continuously at a slower pace. The purpose of this study is to compare the effects of HIIGT to traditional Moderate Intensity Continuous Gait Training (MICGT) in pwMS.

Detailed Description

Purpose: To determine whether pwMS will have greater improvements in gait with HIIGT as compared to MICGT. Primary Question: Does HIIGT results in greater improvements in gait parameters in pwMS than MICGT? Secondary question: Will HIIGT result in greater improvements in balance, lower extremity strength, lower extremity range of motion and HR when compared to MICGT in pwMS? Hypothesis: HIIGT will result in greater improvements in gait parameters in pwMS than MICGT. Justification: Previous research has shown that MICGT, moderate intensity interval training and high intensity non-gait interval training is effective in pwMS. HIIGT has been shown to be effective in persons with stroke but the effects of HIIGT on pwMS are not known. Outcomes and dissemination of information: We will present our findings at national conferences and submit manuscripts of our findings to the appropriate peer reviewed journal.

Registry
clinicaltrials.gov
Start Date
September 1, 2022
End Date
December 31, 2023
Last Updated
3 years ago
Study Type
Interventional
Study Design
Parallel
Sex
All

Investigators

Sponsor
Hunter College of City University of New York
Responsible Party
Principal Investigator
Principal Investigator

Herbert Karpatkin

Associate professor

Hunter College of City University of New York

Eligibility Criteria

Inclusion Criteria

  • Persons diagnosed with Multiple Sclerosis.
  • The ability to walk for 6 minutes continuously with or without assistive device.
  • The ability to read, understand and sign a consent form so that they are able to understand the study we are doing
  • Above the age of 18

Exclusion Criteria

  • Any cardiopulmonary, orthopedic, or non-MS neurologic disease as we are only examining the effects of MS and need to rule out the impact of other conditions
  • Report of a recent exacerbation. Rationale: the impact of the rationale can interfere with the impact of the independent variables

Outcomes

Primary Outcomes

Change in Six minute walk test time from before to after the intervention

Time Frame: The test will be administered to all subjects one week before and one week after the intervention.The test will be administered to all subjects one week before and one week after the intervention.

Subjects will walk for six minutes at their best comfortable pace. They will be guarded by physical therapist for the entire walk. Total distance, distance per minute, and heart rate will be measured.

Secondary Outcomes

  • Change in Hand held dynamometry values from before to after the intervention(Will be done the week before and the week after the intervention.)
  • Change in Multiple sclerosis impact scale 29 from before to afterthe intervention(Performed in the week before and the week after the intervention.)
  • Change in Functional gait assessment score from before to after the intervention(Will be done in the week before and the week after the intervention.Will be done in the week before and the week after the intervention.)

Study Sites (1)

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