Does Preconditioning Affects Other Organs in Patients Undergoing Open Heart Surgery ?

Not Applicable

Completed

• Conditions: Neutrophil Lymphocyte Ratio; Mechanical Ventilation; Serum Createnine
• Interventions: Procedure: ischemic preconditioning; Drug: Pharmacologic preconditionig

• Registration Number: NCT03097692
• Lead Sponsor: Assiut University

Brief Summary

An association between white blood cell count (WBC), neutrophil-lymphocyte ratio , and inflammatory process is well known . Ischemic preconditioning reduces the inflammation

Detailed Description

Preliminary evidence has suggested the role of inflammation in development and prognosis of cardiovascular diseases and cancers. Most of the prognostic studies failed to account for the effects of co-morbid conditions as these might have raised the systemic inflammation. We used neutrophil lymphocyte ratio (NLR) as a measure of systemic inflammation and investigated its association with cardiac preconditioning in open heart surgery .

Study Timeline

• Study Start: 2016-05
• Primary Completion: 2016-12
• Study Completion: 2017-03
• Study First Submitted: 2017-03-21
• Study First Submitted QC: 2017-03-26
• Study First Posted: 2017-03-31
• Status Verified: 2017-12
• Last Update Submitted: 2017-12-20
• Last Update Posted: 2017-12-21

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 100

Inclusion Criteria

• 18-60 years old
• American Society of Anesthesiologists physical status II and III
• Patients scheduled for open heart surgery
• no active inflammatory process

Exclusion Criteria

Exclusion Criteria:

• Emergency surgery
• Clinically significant kidney or liver disease
• Patients allergic to local anesthetic
• Patients with prolonged cardiopulmonary bypass time (>120 min)
• Patients required intra-aortic balloon pump
• Postoperative hemodynamic instability (including the occurrence of serious arrhythmia) or bleeding that required surgical re-exploration

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
Ischemic preconditioing	ischemic preconditioning	50 patients ischemic preconditioning will be done after induction and before cardiopulmonary bypass by inflation the cuff of blood pressure above 200mmhg in the lower limb every 5 min for 3cycles
Pharmacologic preconditioing	Pharmacologic preconditionig	by sevoflurane anesthesia

Primary Outcome Measures

Name	Time	Method
change of Neutrophil lymphocyte ratio	during first two postoperative days

Trial Locations

Locations (1)

Emad Zarief Kamel Said; 🇪🇬 Assiut, Egypt