The Relationship Between Microbiota and Coronary Ectasia

Completed

• Conditions: Microbial Disease; Coronary Ectasia
• Interventions: Diagnostic Test: Taking blood for kit study

• Registration Number: NCT06384703
• Lead Sponsor: Konya Beyhekim Training and Research Hospital

Brief Summary

Introduction: It is now known that the microbiota is far beyond the microbial communities living in certain parts of our body and functions like a metabolic organ. In addition, the microbiota, through its metabolites, is involved in the pathophysiology or progression of a wide range of diseases, from atherosclerotic diseases to metabolic diseases and even neurological diseases. Among these metabolites, trimethylamine n-oxide metabolite has been shown to be particularly effective on atherosclerotic heart diseases.

Detailed Description

Not available

Study Timeline

• Study Start: 2020-11-03
• Primary Completion: 2021-04-25
• Status Verified: 2021-05
• Study Completion: 2021-06-18
• Study First Submitted: 2024-04-16
• Study First Submitted QC: 2024-04-24
• Last Update Submitted: 2024-04-24
• Study First Posted: 2024-04-25
• Last Update Posted: 2024-04-25

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 2

Inclusion Criteria

• over 18 years old
• not having occlusive coronary artery disease
• having coronary ectasia

Exclusion Criteria

• patients with chronic kidney disease,
• revascularized coronary artery disease,
• previously documented critical coronary stenosis,
• acute or chronic inflammatory disease,
• rheumatologic disease,
• known active malignant disease,
• heart failure,
• moderate-to-severe valvular pathology
• patients who were on any steroid or immunosuppressive therapy

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
coronary ectasia cohort	Taking blood for kit study	Patients with coronary ectasia detected on coronary angiography and without any exclusion criteria were included.
normal coronary cohort	Taking blood for kit study	Patients who underwent coronary angiography and did not have any of the exclusion criteria

Primary Outcome Measures

Name	Time	Method
death	1 month	Death from any cause within the last month

Trial Locations

Locations (1)

Necmettin Erbakan University; 🇹🇷 Konya, Turkey