Pistachios, Performance, Metabolomics

Not Applicable

Completed

• Conditions: Inflammation; Immune Dysfunction; Oxidative Stress
• Interventions: Other: Pistachios

• Registration Number: NCT01821820
• Lead Sponsor: Appalachian State University

Brief Summary

Ingestion of 3 ounces of pistachio nuts per day for two weeks before and the day of cycling intensely for 75 kilometers will support substrate utilization during exercise (as determined through metabolomics) and improve performance compared to water only, and attenuate inflammation, oxidative stress, and immune dysfunction during 24 hours of recovery.

Detailed Description

Not available

Study Timeline

• Study Start: 2013-03
• Study First Submitted: 2013-03-27
• Study First Submitted QC: 2013-03-29
• Study First Posted: 2013-04-01
• Primary Completion: 2014-06
• Study Completion: 2014-07
• Status Verified: 2015-01
• Last Update Submitted: 2015-01-30
• Last Update Posted: 2015-02-02

Recruitment & Eligibility

• Status: COMPLETED
• Sex: Male
• Target Recruitment: 40

Inclusion Criteria

• Male endurance cyclists
• Capable of exercising for 2.5 h at a high intensity in the lab
• Ages 18-55
• Agree to train normally and stay weight stable.
• Agree to avoid the use of large dose vitamin/mineral supplements
• Agree to avoid herbs and medications that influence inflammation

Exclusion Criteria

• Regularly take supplements or medicines known to effect inflammation.
• At moderate or high risk for cardiovascular disease.
• Younger than 18 or older than 55 years of age.
• No history of competing in cycling races.

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: CROSSOVER

Arm && Interventions

Group	Intervention	Description
Pistachios	Pistachios	Pistachio treatment (3 oz/d) for two weeks; 3 oz pistachio nuts and water (1.5 oz. before, and 1.5 oz during) cycling 75 km.

Primary Outcome Measures

Name	Time	Method
Shifts in metabolites (metabolomics)	14-day period	Shifts in metabolites pre-and post-14-days supplementation, and then after 75-km cycling, and the next morning.

Secondary Outcome Measures

Name	Time	Method
Immune Function	14-day period	Pre- and post-14 days supplementation, and following 75-km cycling; granulocyte and monocyte phagocytosis and oxidative burst activity; leukoycte differential
Inflammation	14-day period	Pre- and post-14 d supplementation, and following 75-km cycling; plasma IL-6, IL-8, IL-10, TNF-alpha, G-CSF, MCP-1; C-reactive protein
Oxidative Stress	14-day period	Pre- and post-14 days supplementation, and following 75-km cycling; RBC glutathione, protein carbonyls, ORAC, FRAP, F2-isoprostanes

Trial Locations

Locations (1)

ASU Human Performance Laboratory, North Carolina Research Campus; 🇺🇸 Kannapolis, North Carolina, United States