Effects of various doses of statin therapy on the endothelial function in young adults with familial hypercholesterolemia.

• Registration Number: NL-OMON23698
• Lead Sponsor: -

Brief Summary

/A

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Last Update Posted: 28 February 2024

Recruitment & Eligibility

• Status: Pending
• Sex: Not specified
• Target Recruitment: 40

Inclusion Criteria

Healthy heterozygous FH patients aged >18 years with a documented LDL receptor mutation and LDL cholesterol level above the 95th percentile for age and gender. Or LDL cholesterol above 95st percentile and a positive family history for FH or premature CAD.

Exclusion Criteria

Females who are pregnant or intend to become pregnant; hypersensitivity or contraidication to simvastatin; excessive alcohol consumption, smoking or drug abuse.

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
The effect of various doses of simvastatin (5-40 mg) on endothelial function as measured by flow mediated dilatation (FMD) compared to placebo.

Secondary Outcome Measures

Name	Time	Method
The cholesterol lowering effect of the various dosages simvastatin campared to placebo.